Hao Y - Search Results

1

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Hao Y, Lyu J, Qu R, Tong Y, Sun D, Feng F, Tong L, Yang T, Zhao Z, Zhu L, Ding J, Xu Y, Xie H, Li H. Hao Y, et al. J Med Chem. 2018 Jul 12;61(13):5609-5622. doi: 10.1021/acs.jmedchem.8b00346. Epub 2018 Jun 25. J Med Chem. 2018. PMID: 29906114

2

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Hao Y, Wang X, Zhang T, Sun D, Tong Y, Xu Y, Chen H, Tong L, Zhu L, Zhao Z, Chen Z, Ding J, Xie H, Xu Y, Li H. Hao Y, et al. J Med Chem. 2016 Aug 11;59(15):7111-24. doi: 10.1021/acs.jmedchem.6b00403. Epub 2016 Jul 21. J Med Chem. 2016. PMID: 27396610

3

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.

Hao Y, Lyu J, Qu R, Sun D, Zhao Z, Chen Z, Ding J, Xie H, Xu Y, Li H. Hao Y, et al. Sci Rep. 2017 Jun 19;7(1):3830. doi: 10.1038/s41598-017-04184-9. Sci Rep. 2017. PMID: 28630494 Free PMC article.

4

Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors.

Chen H, Song P, Diao Y, Hao Y, Dou D, Wang W, Fang X, Wang Y, Zhao Z, Ding J, Li H, Xie H, Xu Y. Chen H, et al. Among authors: hao y. Medchemcomm. 2018 Mar 13;9(4):697-704. doi: 10.1039/c8md00019k. eCollection 2018 Apr 1. Medchemcomm. 2018. PMID: 30108960 Free PMC article.

5

Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.

Diao Y, Fang X, Song P, Lai M, Tong L, Hao Y, Dou D, Liu Y, Ding J, Zhao Z, Xie H, Li H. Diao Y, et al. Among authors: hao y. Bioorg Med Chem. 2019 Aug 1;27(15):3390-3395. doi: 10.1016/j.bmc.2019.06.023. Epub 2019 Jun 12. Bioorg Med Chem. 2019. PMID: 31221612

6

A highly efficient metal-free selective 1,4-addition of difluoroenoxysilanes to chromones.

Wang XY, Yang M, Zhou Y, Zhou J, Hao YJ. Wang XY, et al. Among authors: hao yj. Org Biomol Chem. 2023 Feb 1;21(5):1033-1037. doi: 10.1039/d2ob02152h. Org Biomol Chem. 2023. PMID: 36625240

7

Enantioselective Synthesis of Bispiro[indanedione-oxindole-cyclopropane]s through Organocatalytic [2+1] Cycloaddition.

Hao ZF, Zhu SJ, Hao YJ, Zhang WH, Zhou Y, Tian YP, Lei CW. Hao ZF, et al. Among authors: hao yj. J Org Chem. 2023 Jun 16;88(12):7641-7650. doi: 10.1021/acs.joc.2c01009. Epub 2022 Aug 12. J Org Chem. 2023. PMID: 35960861

8

Construction of β-Quaternary α,α-Difluoroketones via Catalytic Nucleophilic Substitution of Tertiary Alcohols with Difluoroenoxysilanes.

Hao YJ, Gong Y, Zhou Y, Zhou J, Yu JS. Hao YJ, et al. Org Lett. 2020 Nov 6;22(21):8516-8521. doi: 10.1021/acs.orglett.0c03123. Epub 2020 Oct 13. Org Lett. 2020. PMID: 33048558

9

Etiological features of status epilepticus of the in-patient cohort in Tibet: A retrospective comparative study.

Peng W, Lu L, Hao Y, Xiong W, Abdulaziz AT, Lian Y, Chen L, Wu X, Zhao Y, Zhou D. Peng W, et al. Among authors: hao y. Seizure. 2025 Jan 11;125:179-185. doi: 10.1016/j.seizure.2025.01.001. Online ahead of print. Seizure. 2025. PMID: 39862626

10

Epiregulin ameliorates ovariectomy-induced bone loss through orchestrating the differentiation of osteoblasts and osteoclasts.

Dong Y, Wu X, Hao Y, Liu W, Hu X, Zhou J, Li X, Wang B. Dong Y, et al. Among authors: hao y. J Bone Miner Res. 2025 Jan 25:zjaf017. doi: 10.1093/jbmr/zjaf017. Online ahead of print. J Bone Miner Res. 2025. PMID: 39862425

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