Li H - Search Results

1

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Hao Y, Lyu J, Qu R, Tong Y, Sun D, Feng F, Tong L, Yang T, Zhao Z, Zhu L, Ding J, Xu Y, Xie H, Li H. Hao Y, et al. Among authors: li h. J Med Chem. 2018 Jul 12;61(13):5609-5622. doi: 10.1021/acs.jmedchem.8b00346. Epub 2018 Jun 25. J Med Chem. 2018. PMID: 29906114

2

Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme.

Chen L, Li H, Liu J, Zhang L, Liu H, Jiang H. Chen L, et al. Among authors: li h. Bioorg Med Chem. 2007 Nov 1;15(21):6763-74. doi: 10.1016/j.bmc.2007.08.003. Epub 2007 Aug 10. Bioorg Med Chem. 2007. PMID: 17719791

3

Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.

Lin LG, Xie H, Li HL, Tong LJ, Tang CP, Ke CQ, Liu QF, Lin LP, Geng MY, Jiang H, Zhao WM, Ding J, Ye Y. Lin LG, et al. Among authors: li hl. J Med Chem. 2008 Aug 14;51(15):4419-29. doi: 10.1021/jm701501x. Epub 2008 Jul 9. J Med Chem. 2008. PMID: 18610999

4

Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.

He L, Zhang L, Liu X, Li X, Zheng M, Li H, Yu K, Chen K, Shen X, Jiang H, Liu H. He L, et al. Among authors: li x, li h. J Med Chem. 2009 Apr 23;52(8):2465-81. doi: 10.1021/jm8015602. J Med Chem. 2009. PMID: 19309082

5

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Li H, Huang J, Chen L, Liu X, Chen T, Zhu J, Lu W, Shen X, Li J, Hilgenfeld R, Jiang H. Li H, et al. Among authors: li j. J Med Chem. 2009 Aug 13;52(15):4936-40. doi: 10.1021/jm801622x. J Med Chem. 2009. PMID: 19586036

6

Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.

Zhang L, Li H, Zhu Q, Liu J, Chen L, Leng Y, Jiang H, Liu H. Zhang L, et al. Among authors: li h. Bioorg Med Chem. 2009 Oct 15;17(20):7301-12. doi: 10.1016/j.bmc.2009.08.045. Epub 2009 Aug 24. Bioorg Med Chem. 2009. PMID: 19758809

7

Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.

Liu X, Xie H, Luo C, Tong L, Wang Y, Peng T, Ding J, Jiang H, Li H. Liu X, et al. Among authors: li h. J Med Chem. 2010 Mar 25;53(6):2661-5. doi: 10.1021/jm901798e. J Med Chem. 2010. PMID: 20178321 Free article.

8

New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein.

Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D, Ke D. Liu X, et al. Among authors: li h. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52. doi: 10.1016/j.bmcl.2011.03.063. Epub 2011 Mar 22. Bioorg Med Chem Lett. 2011. PMID: 21481589

9

SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.

Lu W, Liu X, Cao X, Xue M, Liu K, Zhao Z, Shen X, Jiang H, Xu Y, Huang J, Li H. Lu W, et al. Among authors: li h. J Med Chem. 2011 May 26;54(10):3564-74. doi: 10.1021/jm200139j. Epub 2011 Apr 22. J Med Chem. 2011. PMID: 21488662

10

Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.

Chen Z, Wang X, Zhu W, Cao X, Tong L, Li H, Xie H, Xu Y, Tan S, Kuang D, Ding J, Qian X. Chen Z, et al. Among authors: li h. J Med Chem. 2011 Jun 9;54(11):3732-45. doi: 10.1021/jm200258t. Epub 2011 May 13. J Med Chem. 2011. PMID: 21517068

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