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Page 1
Coactivator condensation at super-enhancers links phase separation and gene control.
Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA. Sabari BR, et al. Among authors: zamudio av. Science. 2018 Jul 27;361(6400):eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21. Science. 2018. PMID: 29930091 Free PMC article.
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA. Boija A, et al. Among authors: zamudio av. Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15. Cell. 2018. PMID: 30449618 Free PMC article.
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, Lee TI, Cisse II, Sharp PA, Taatjes DJ, Young RA. Guo YE, et al. Among authors: zamudio av. Nature. 2019 Aug;572(7770):543-548. doi: 10.1038/s41586-019-1464-0. Epub 2019 Aug 7. Nature. 2019. PMID: 31391587 Free PMC article.
Enhancer Features that Drive Formation of Transcriptional Condensates.
Shrinivas K, Sabari BR, Coffey EL, Klein IA, Boija A, Zamudio AV, Schuijers J, Hannett NM, Sharp PA, Young RA, Chakraborty AK. Shrinivas K, et al. Among authors: zamudio av. Mol Cell. 2019 Aug 8;75(3):549-561.e7. doi: 10.1016/j.molcel.2019.07.009. Mol Cell. 2019. PMID: 31398323 Free PMC article.
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.
Zamudio AV, Dall'Agnese A, Henninger JE, Manteiga JC, Afeyan LK, Hannett NM, Coffey EL, Li CH, Oksuz O, Sabari BR, Boija A, Klein IA, Hawken SW, Spille JH, Decker TM, Cisse II, Abraham BJ, Lee TI, Taatjes DJ, Schuijers J, Young RA. Zamudio AV, et al. Mol Cell. 2019 Dec 5;76(5):753-766.e6. doi: 10.1016/j.molcel.2019.08.016. Epub 2019 Sep 25. Mol Cell. 2019. PMID: 31563432 Free PMC article.
Partitioning of cancer therapeutics in nuclear condensates.
Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, Zamudio AV, Manteiga JC, Coffey EL, Li CH, Hannett NM, Guo YE, Decker TM, Lee TI, Zhang T, Weng JK, Taatjes DJ, Chakraborty A, Sharp PA, Chang YT, Hyman AA, Gray NS, Young RA. Klein IA, et al. Among authors: zamudio av. Science. 2020 Jun 19;368(6497):1386-1392. doi: 10.1126/science.aaz4427. Science. 2020. PMID: 32554597 Free PMC article.
RNA-Mediated Feedback Control of Transcriptional Condensates.
Henninger JE, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng MM, Andrews JO, Zamudio AV, Lazaris C, Hannett NM, Lee TI, Sharp PA, Cissé II, Chakraborty AK, Young RA. Henninger JE, et al. Among authors: zamudio av. Cell. 2021 Jan 7;184(1):207-225.e24. doi: 10.1016/j.cell.2020.11.030. Epub 2020 Dec 16. Cell. 2021. PMID: 33333019 Free PMC article.
YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA. Weintraub AS, et al. Among authors: zamudio av. Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7. Cell. 2017. PMID: 29224777 Free PMC article.
MeCP2 links heterochromatin condensates and neurodevelopmental disease.
Li CH, Coffey EL, Dall'Agnese A, Hannett NM, Tang X, Henninger JE, Platt JM, Oksuz O, Zamudio AV, Afeyan LK, Schuijers J, Liu XS, Markoulaki S, Lungjangwa T, LeRoy G, Svoboda DS, Wogram E, Lee TI, Jaenisch R, Young RA. Li CH, et al. Among authors: zamudio av. Nature. 2020 Oct;586(7829):440-444. doi: 10.1038/s41586-020-2574-4. Epub 2020 Jul 22. Nature. 2020. PMID: 32698189 Free PMC article.
13 results