Atobe M - Search Results

1

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP₁ receptor antagonist and in vivo studies in a bone fracture model.

Atobe M, Naganuma K, Kawanishi M, Hayashi T, Suzuki H, Nishida M, Arai H. Atobe M, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2408-2412. doi: 10.1016/j.bmcl.2018.06.022. Epub 2018 Jun 19. Bioorg Med Chem Lett. 2018. PMID: 29934246

2

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.

Atobe M, Maekawara N, Ishiguro N, Sogame S, Suenaga Y, Kawanishi M, Suzuki H, Jinno N, Tanaka E, Miyoshi S. Atobe M, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2106-10. doi: 10.1016/j.bmcl.2013.01.121. Epub 2013 Feb 9. Bioorg Med Chem Lett. 2013. PMID: 23453070

3

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors.

Atobe M, Maekawara N, Kawanishi M, Suzuki H, Tanaka E, Miyoshi S. Atobe M, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2111-6. doi: 10.1016/j.bmcl.2013.01.120. Epub 2013 Feb 9. Bioorg Med Chem Lett. 2013. PMID: 23453072

4

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6064-7. doi: 10.1016/j.bmcl.2013.09.032. Epub 2013 Sep 19. Bioorg Med Chem Lett. 2013. PMID: 24094816

5

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6569-76. doi: 10.1016/j.bmcl.2013.10.065. Epub 2013 Nov 6. Bioorg Med Chem Lett. 2013. PMID: 24252546

6

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.

Sogame S, Suenaga Y, Atobe M, Kawanishi M, Tanaka E, Miyoshi S. Sogame S, et al. Among authors: atobe m. Eur J Med Chem. 2014 Jan;71:250-8. doi: 10.1016/j.ejmech.2013.10.075. Epub 2013 Nov 15. Eur J Med Chem. 2014. PMID: 24316668

7

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1327-33. doi: 10.1016/j.bmcl.2014.01.052. Epub 2014 Jan 28. Bioorg Med Chem Lett. 2014. PMID: 24508133

8

Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

Lüthy M, Wheldon MC, Haji-Cheteh C, Atobe M, Bond PS, O'Brien P, Hubbard RE, Fairlamb IJ. Lüthy M, et al. Among authors: atobe m. Bioorg Med Chem. 2015 Jun 1;23(11):2680-94. doi: 10.1016/j.bmc.2015.04.005. Epub 2015 Apr 11. Bioorg Med Chem. 2015. PMID: 25936257

9

A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.

Atobe M, Yamakawa N, Wada Y, Goto T, Kawanishi M, Ito T, Saito M, Takeda M, Tabata T, Arai H. Atobe M, et al. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4828-4831. doi: 10.1016/j.bmcl.2017.09.049. Epub 2017 Sep 25. Bioorg Med Chem Lett. 2017. PMID: 28988762

10

Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.

Atobe M, Nagami T, Muramatsu S, Ohno T, Kitagawa M, Suzuki H, Ishiguro M, Watanabe A, Kawanishi M. Atobe M, et al. J Med Chem. 2019 Feb 14;62(3):1468-1483. doi: 10.1021/acs.jmedchem.8b01615. Epub 2019 Jan 28. J Med Chem. 2019. PMID: 30629441

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