Tumbale P - Search Results

1

Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.

Tumbale P, Schellenberg MJ, Mueller GA, Fairweather E, Watson M, Little JN, Krahn J, Waddell I, London RE, Williams RS. Tumbale P, et al. EMBO J. 2018 Jul 13;37(14):e98875. doi: 10.15252/embj.201798875. Epub 2018 Jun 22. EMBO J. 2018. PMID: 29934293 Free PMC article.

2

Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.

Schellenberg MJ, Tumbale PP, Williams RS. Schellenberg MJ, et al. Among authors: tumbale pp. Prog Biophys Mol Biol. 2015 Mar;117(2-3):157-165. doi: 10.1016/j.pbiomolbio.2015.01.007. Epub 2015 Jan 29. Prog Biophys Mol Biol. 2015. PMID: 25637650 Free PMC article. Review.

3

Two-tiered enforcement of high-fidelity DNA ligation.

Tumbale PP, Jurkiw TJ, Schellenberg MJ, Riccio AA, O'Brien PJ, Williams RS. Tumbale PP, et al. Nat Commun. 2019 Nov 28;10(1):5431. doi: 10.1038/s41467-019-13478-7. Nat Commun. 2019. PMID: 31780661 Free PMC article.

4

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, Pedersen LC, Bebenek K. Kaminski AM, et al. Among authors: tumbale pp. Nat Commun. 2018 Jul 6;9(1):2642. doi: 10.1038/s41467-018-05024-8. Nat Commun. 2018. PMID: 29980672 Free PMC article.

5

LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.

Jurkiw TJ, Tumbale PP, Schellenberg MJ, Cunningham-Rundles C, Williams RS, O'Brien PJ. Jurkiw TJ, et al. Among authors: tumbale pp. Nucleic Acids Res. 2021 Feb 22;49(3):1619-1630. doi: 10.1093/nar/gkaa1297. Nucleic Acids Res. 2021. PMID: 33444456 Free PMC article.

6

Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.

Tumbale P, Appel CD, Kraehenbuehl R, Robertson PD, Williams JS, Krahn J, Ahel I, Williams RS. Tumbale P, et al. Nat Struct Mol Biol. 2011 Oct 9;18(11):1189-95. doi: 10.1038/nsmb.2146. Nat Struct Mol Biol. 2011. PMID: 21984210 Free PMC article.

7

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.

Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS. Tumbale P, et al. Nature. 2014 Feb 6;506(7486):111-5. doi: 10.1038/nature12824. Epub 2013 Dec 22. Nature. 2014. PMID: 24362567 Free PMC article.

8

Recognition and repair of chemically heterogeneous structures at DNA ends.

Andres SN, Schellenberg MJ, Wallace BD, Tumbale P, Williams RS. Andres SN, et al. Among authors: tumbale p. Environ Mol Mutagen. 2015 Jan;56(1):1-21. doi: 10.1002/em.21892. Epub 2014 Aug 11. Environ Mol Mutagen. 2015. PMID: 25111769 Free PMC article. Review.

9

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.

Williams JS, Tumbale PP, Arana ME, Rana JA, Williams RS, Kunkel TA. Williams JS, et al. Among authors: tumbale pp. Nat Commun. 2021 Jan 20;12(1):482. doi: 10.1038/s41467-020-20800-1. Nat Commun. 2021. PMID: 33473124 Free PMC article.

10

Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.

Fleming MC, Chiou LF, Tumbale PP, Droby GN, Lim J, Norris-Drouin JL, Williams JG, Pearce KH, Williams RS, Vaziri C, Bowers AA. Fleming MC, et al. Among authors: tumbale pp. J Med Chem. 2022 May 26;65(10):7231-7245. doi: 10.1021/acs.jmedchem.2c00185. Epub 2022 May 6. J Med Chem. 2022. PMID: 35522528 Free PMC article.

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