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Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV. Talebi A, et al. Among authors: marine jc. Nat Commun. 2018 Jun 27;9(1):2500. doi: 10.1038/s41467-018-04664-0. Nat Commun. 2018. PMID: 29950559 Free PMC article.
MDM4 is a key therapeutic target in cutaneous melanoma.
Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC. Gembarska A, et al. Among authors: marine jc. Nat Med. 2012 Aug;18(8):1239-47. doi: 10.1038/nm.2863. Epub 2012 Jul 22. Nat Med. 2012. PMID: 22820643 Free PMC article.
IGF2: the Achilles' heel of p53-deficiency?
Clermont F, Nittner D, Marine JC. Clermont F, et al. Among authors: marine jc. EMBO Mol Med. 2012 Aug;4(8):688-90. doi: 10.1002/emmm.201201509. Epub 2012 Jul 24. EMBO Mol Med. 2012. PMID: 22829471 Free PMC article. No abstract available.
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state.
Verfaillie A, Imrichova H, Atak ZK, Dewaele M, Rambow F, Hulselmans G, Christiaens V, Svetlichnyy D, Luciani F, Van den Mooter L, Claerhout S, Fiers M, Journe F, Ghanem GE, Herrmann C, Halder G, Marine JC, Aerts S. Verfaillie A, et al. Among authors: marine jc. Nat Commun. 2015 Apr 9;6:6683. doi: 10.1038/ncomms7683. Nat Commun. 2015. PMID: 25865119 Free PMC article.
p53 attenuates AKT signaling by modulating membrane phospholipid composition.
Rueda-Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, Khan NA, Dehairs J, Bagadi M, Binda MM, Waelkens E, Marine JC, Swinnen JV. Rueda-Rincon N, et al. Among authors: marine jc. Oncotarget. 2015 Aug 28;6(25):21240-54. doi: 10.18632/oncotarget.4067. Oncotarget. 2015. PMID: 26061814 Free PMC article.
Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.
Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo SX, Low DH, Koh CM, Rambow F, Fiers M, Rogiers A, Radaelli E, Al-Haddawi M, Tan SY, Hermans E, Amant F, Yan H, Lakshmanan M, Koumar RC, Lim ST, Derheimer FA, Campbell RM, Bonday Z, Tergaonkar V, Shackleton M, Blattner C, Marine JC, Guccione E. Dewaele M, et al. Among authors: marine jc. J Clin Invest. 2016 Jan;126(1):68-84. doi: 10.1172/JCI82534. Epub 2015 Nov 23. J Clin Invest. 2016. PMID: 26595814 Free PMC article.
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