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Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats.
Ye ZN, Wu LY, Liu JP, Chen Q, Zhang XS, Lu Y, Zhou ML, Li W, Zhang ZH, Xia DY, Zhuang Z, Hang CH. Ye ZN, et al. Among authors: lu y. Behav Brain Res. 2018 Feb 26;339:19-27. doi: 10.1016/j.bbr.2017.11.011. Epub 2017 Nov 11. Behav Brain Res. 2018. PMID: 29133197
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
Zhang X, Lu Y, Wu Q, Dai H, Li W, Lv S, Zhou X, Zhang X, Hang C, Wang J. Zhang X, et al. Among authors: lu y. FASEB J. 2019 Jan;33(1):722-737. doi: 10.1096/fj.201800642RR. Epub 2018 Jul 26. FASEB J. 2019. PMID: 30048156
These results suggest that ATX reduces the proinflammatory response and secondary brain injury after SAH, primarily by increasing sirtuin 1 levels and inhibiting the TLR4 signaling pathway.-Zhang, X., Lu, Y., Wu, Q., Dai, H., Li, W., Lv, S., Zhou, X., Zhang, X., Han …
These results suggest that ATX reduces the proinflammatory response and secondary brain injury after SAH, primarily by increasing sirtuin 1 …
Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage.
Lu Y, Zhang XS, Zhou XM, Gao YY, Chen CL, Liu JP, Ye ZN, Zhang ZH, Wu LY, Li W, Hang CH. Lu Y, et al. FASEB J. 2019 Feb;33(2):3051-3062. doi: 10.1096/fj.201801150R. Epub 2018 Oct 23. FASEB J. 2019. PMID: 30351993
Thus, early expression of Prx1/2 may protect the brain from oxidative damage after SAH and may provide a novel target for treating SAH.-Lu, Y., Zhang, X.-S., Zhou, X.-M., Gao, Y.-Y., Chen, C.-L., Liu, J.-P., Ye, Z.-N., Zhang, Z.-H., Wu, L.-Y., L …
Thus, early expression of Prx1/2 may protect the brain from oxidative damage after SAH and may provide a novel target for treating SAH.-L
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