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OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.
van der Pol A, Gil A, Tromp J, Silljé HHW, van Veldhuisen DJ, Voors AA, Hoendermis ES, Grote Beverborg N, Schouten EM, de Boer RA, Bischoff R, van der Meer P. van der Pol A, et al. Among authors: gil a. Cardiovasc Res. 2018 Dec 1;114(14):1871-1882. doi: 10.1093/cvr/cvy187. Cardiovasc Res. 2018. PMID: 30032247
Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.
van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P. van der Pol A, et al. Among authors: gil a. Sci Transl Med. 2017 Nov 8;9(415):eaam8574. doi: 10.1126/scitranslmed.aam8574. Sci Transl Med. 2017. PMID: 29118264
1,775 results