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Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG. Martinez-Chacin RC, et al. Among authors: grant gd. Nat Struct Mol Biol. 2020 Jun;27(6):550-560. doi: 10.1038/s41594-020-0424-6. Epub 2020 May 11. Nat Struct Mol Biol. 2020. PMID: 32393902 Free PMC article.
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. McDonald IM, et al. Among authors: grant gd. J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896573 Free PMC article.
Sequential replication-coupled destruction at G1/S ensures genome stability.
Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG. Coleman KE, et al. Among authors: grant gd. Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13. Genes Dev. 2015. PMID: 26272819 Free PMC article.
80 results