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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths.
Ruuth M, Nguyen SD, Vihervaara T, Hilvo M, Laajala TD, Kondadi PK, Gisterå A, Lähteenmäki H, Kittilä T, Huusko J, Uusitupa M, Schwab U, Savolainen MJ, Sinisalo J, Lokki ML, Nieminen MS, Jula A, Perola M, Ylä-Herttula S, Rudel L, Öörni A, Baumann M, Baruch A, Laaksonen R, Ketelhuth DFJ, Aittokallio T, Jauhiainen M, Käkelä R, Borén J, Williams KJ, Kovanen PT, Öörni K. Ruuth M, et al. Among authors: vihervaara t. Eur Heart J. 2018 Jul 14;39(27):2562-2573. doi: 10.1093/eurheartj/ehy319. Eur Heart J. 2018. PMID: 29982602 Free PMC article.
Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.
Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, März W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki ML, Nieminen MS, Klingenberg R, Matter CM, Hornemann T, Jüni P, Rodondi N, Räber L, Windecker S, Gencer B, Pedersen ER, Tell GS, Nygård O, Mach F, Sinisalo J, Lüscher TF. Laaksonen R, et al. Among authors: vihervaara t. Eur Heart J. 2016 Jul 1;37(25):1967-76. doi: 10.1093/eurheartj/ehw148. Epub 2016 Apr 28. Eur Heart J. 2016. PMID: 27125947 Free PMC article.
Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.
Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K. Kiamehr M, et al. Among authors: vihervaara t. Dis Model Mech. 2017 Sep 1;10(9):1141-1153. doi: 10.1242/dmm.030841. Epub 2017 Jul 21. Dis Model Mech. 2017. PMID: 28733363 Free PMC article.
hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver.
Kiamehr M, Alexanova A, Viiri LE, Heiskanen L, Vihervaara T, Kauhanen D, Ekroos K, Laaksonen R, Käkelä R, Aalto-Setälä K. Kiamehr M, et al. Among authors: vihervaara t. J Cell Physiol. 2019 Apr;234(4):3744-3761. doi: 10.1002/jcp.27131. Epub 2018 Aug 26. J Cell Physiol. 2019. PMID: 30146765
Lipidomics in drug discovery.
Vihervaara T, Suoniemi M, Laaksonen R. Vihervaara T, et al. Drug Discov Today. 2014 Feb;19(2):164-70. doi: 10.1016/j.drudis.2013.09.008. Epub 2013 Sep 17. Drug Discov Today. 2014. PMID: 24055840 Review.
Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study.
Cheng JM, Suoniemi M, Kardys I, Vihervaara T, de Boer SP, Akkerhuis KM, Sysi-Aho M, Ekroos K, Garcia-Garcia HM, Oemrawsingh RM, Regar E, Koenig W, Serruys PW, van Geuns RJ, Boersma E, Laaksonen R. Cheng JM, et al. Among authors: vihervaara t. Atherosclerosis. 2015 Dec;243(2):560-6. doi: 10.1016/j.atherosclerosis.2015.10.022. Epub 2015 Oct 23. Atherosclerosis. 2015. PMID: 26523994 Clinical Trial.
Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis.
Titz B, Boué S, Phillips B, Talikka M, Vihervaara T, Schneider T, Nury C, Elamin A, Guedj E, Peck MJ, Schlage WK, Cabanski M, Leroy P, Vuillaume G, Martin F, Ivanov NV, Veljkovic E, Ekroos K, Laaksonen R, Vanscheeuwijck P, Peitsch MC, Hoeng J. Titz B, et al. Among authors: vihervaara t. Toxicol Sci. 2016 Feb;149(2):441-57. doi: 10.1093/toxsci/kfv244. Epub 2015 Nov 17. Toxicol Sci. 2016. PMID: 26582801 Free PMC article.
31 results