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A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. Tsuburaya N, et al. Among authors: imamura k. Nat Commun. 2018 Jul 10;9(1):2668. doi: 10.1038/s41467-018-05127-2. Nat Commun. 2018. PMID: 29991716 Free PMC article.
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H. Kondo T, et al. Among authors: imamura k. Cell Stem Cell. 2013 Apr 4;12(4):487-96. doi: 10.1016/j.stem.2013.01.009. Epub 2013 Feb 21. Cell Stem Cell. 2013. PMID: 23434393 Free article.
Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.
Murakami N, Imamura K, Izumi Y, Egawa N, Tsukita K, Enami T, Yamamoto T, Kawarai T, Kaji R, Inoue H. Murakami N, et al. Among authors: imamura k. Mol Brain. 2017 Feb 15;10(1):7. doi: 10.1186/s13041-017-0286-y. Mol Brain. 2017. PMID: 28196470 Free PMC article.
Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors.
Goto K, Imamura K, Komatsu K, Mitani K, Aiba K, Nakatsuji N, Inoue M, Kawata A, Yamashita H, Takahashi R, Inoue H. Goto K, et al. Among authors: imamura k. Mol Ther Methods Clin Dev. 2017 Jan 10;4:115-125. doi: 10.1016/j.omtm.2016.12.007. eCollection 2017 Mar 17. Mol Ther Methods Clin Dev. 2017. PMID: 28344997 Free PMC article.
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H. Imamura K, et al. Sci Transl Med. 2017 May 24;9(391):eaaf3962. doi: 10.1126/scitranslmed.aaf3962. Sci Transl Med. 2017. PMID: 28539470 Free article.
Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs.
Matsuzono K, Imamura K, Murakami N, Tsukita K, Yamamoto T, Izumi Y, Kaji R, Ohta Y, Yamashita T, Abe K, Inoue H. Matsuzono K, et al. Among authors: imamura k. Mol Ther Nucleic Acids. 2017 Sep 15;8:211-219. doi: 10.1016/j.omtn.2017.06.017. Epub 2017 Jun 23. Mol Ther Nucleic Acids. 2017. PMID: 28918022 Free PMC article.
Induced pluripotent stem cells derived from an autosomal dominant lateral temporal epilepsy (ADLTE) patient carrying S473L mutation in leucine-rich glioma inactivated 1 (LGI1).
Tan GW, Kondo T, Murakami N, Imamura K, Enami T, Tsukita K, Shibukawa R, Funayama M, Matsumoto R, Ikeda A, Takahashi R, Inoue H. Tan GW, et al. Among authors: imamura k. Stem Cell Res. 2017 Oct;24:12-15. doi: 10.1016/j.scr.2017.07.030. Epub 2017 Jul 29. Stem Cell Res. 2017. PMID: 29034879 Free article.
1,180 results