Flynn B - Search Results

1

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Among authors: flynn b. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.

2

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

3

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. J Med Chem. 2009 Jul 23;52(14):4543-7. doi: 10.1021/jm9002582. J Med Chem. 2009. PMID: 19514747

4

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Bioorg Med Chem. 2009 Oct 15;17(20):7353-61. doi: 10.1016/j.bmc.2009.08.024. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19751980 Free PMC article.

5

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

Aurelio L, Valant C, Flynn BL, Sexton PM, White JM, Christopoulos A, Scammells PJ. Aurelio L, et al. J Med Chem. 2010 Sep 23;53(18):6550-9. doi: 10.1021/jm1008538. J Med Chem. 2010. PMID: 20806896

6

New methodology for the N-alkylation of 2-amino-3-acylthiophenes.

Aurelio L, Flynn BL, Scammells PJ. Aurelio L, et al. Org Biomol Chem. 2011 Jul 7;9(13):4886-902. doi: 10.1039/c0ob01156h. Epub 2011 May 11. Org Biomol Chem. 2011. PMID: 21562651

7

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio L, Christopoulos A, Flynn BL, Scammells PJ, Sexton PM, Valant C. Aurelio L, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3704-7. doi: 10.1016/j.bmcl.2011.04.080. Epub 2011 May 4. Bioorg Med Chem Lett. 2011. PMID: 21612922

8

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.

Halim R, Aurelio L, Scammells PJ, Flynn BL. Halim R, et al. J Org Chem. 2013 May 17;78(10):4708-18. doi: 10.1021/jo400125p. Epub 2013 May 9. J Org Chem. 2013. PMID: 23659428

9

Mapping the Interactions of I2 , I(.) , I(-) , and I(+) with Alkynes and Their Roles in Iodocyclizations.

Volpe R, Aurelio L, Gillin MG, Krenske EH, Flynn BL. Volpe R, et al. Chemistry. 2015 Jul 6;21(28):10191-9. doi: 10.1002/chem.201500384. Epub 2015 Jun 3. Chemistry. 2015. PMID: 26043933

10

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL. Aurelio L, et al. J Med Chem. 2016 Feb 11;59(3):965-84. doi: 10.1021/acs.jmedchem.5b01439. Epub 2016 Feb 3. J Med Chem. 2016. PMID: 26780304

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