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Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
Bruno F, Errico S, Pace S, Nawrozkij MB, Mkrtchyan AS, Guida F, Maisto R, Olgaç A, D'Amico M, Maione S, De Rosa M, Banoglu E, Werz O, Fiorentino A, Filosa R. Bruno F, et al. Among authors: guida f. Eur J Med Chem. 2018 Jul 15;155:946-960. doi: 10.1016/j.ejmech.2018.05.041. Epub 2018 May 28. Eur J Med Chem. 2018. PMID: 30015253
Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat.
Palazzo E, Guida F, Migliozzi A, Gatta L, Marabese I, Luongo L, Rossi C, de Novellis V, Fernández-Sánchez E, Soukupova M, Zafra F, Maione S. Palazzo E, et al. Among authors: guida f. J Neurophysiol. 2009 Dec;102(6):3169-79. doi: 10.1152/jn.00124.2009. Epub 2009 Sep 23. J Neurophysiol. 2009. PMID: 19776366 Free article.
Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.
Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, Guida F, Luongo L, De Chiaro M, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Di Marzo V, Corelli F. Pasquini S, et al. Among authors: guida f. J Med Chem. 2010 Aug 26;53(16):5915-28. doi: 10.1021/jm100123x. J Med Chem. 2010. PMID: 20718492
Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo.
Aviello G, Borrelli F, Guida F, Romano B, Lewellyn K, De Chiaro M, Luongo L, Zjawiony JK, Maione S, Izzo AA, Capasso R. Aviello G, et al. Among authors: guida f. J Mol Med (Berl). 2011 Sep;89(9):891-902. doi: 10.1007/s00109-011-0752-4. Epub 2011 Apr 16. J Mol Med (Berl). 2011. PMID: 21499737
Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.
Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F. Pasquini S, et al. Among authors: guida f. J Med Chem. 2011 Aug 11;54(15):5444-53. doi: 10.1021/jm200476p. Epub 2011 Jul 6. J Med Chem. 2011. PMID: 21702498
Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity.
de Novellis V, Luongo L, Guida F, Cristino L, Palazzo E, Russo R, Marabese I, D'Agostino G, Calignano A, Rossi F, Di Marzo V, Maione S. de Novellis V, et al. Among authors: guida f. Eur J Pharmacol. 2012 Feb 15;676(1-3):41-50. doi: 10.1016/j.ejphar.2011.11.034. Epub 2011 Dec 3. Eur J Pharmacol. 2012. PMID: 22178921
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.
Mugnaini C, Nocerino S, Pedani V, Pasquini S, Tafi A, De Chiaro M, Bellucci L, Valoti M, Guida F, Luongo L, Dragoni S, Ligresti A, Rosenberg A, Bolognini D, Cascio MG, Pertwee RG, Moaddel R, Maione S, Di Marzo V, Corelli F. Mugnaini C, et al. Among authors: guida f. ChemMedChem. 2012 May;7(5):920-34. doi: 10.1002/cmdc.201100573. Epub 2012 Mar 2. ChemMedChem. 2012. PMID: 22383251 Free PMC article.
Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.
Palazzo E, Luongo L, Bellini G, Guida F, Marabese I, Boccella S, Rossi F, Maione S, de Novellis V. Palazzo E, et al. Among authors: guida f. CNS Neurol Disord Drug Targets. 2012 Mar;11(2):148-61. doi: 10.2174/187152712800269731. CNS Neurol Disord Drug Targets. 2012. PMID: 22483283
293 results