Fischer PM - Search Results

1

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1.

Pearson RJ, Blake DG, Mezna M, Fischer PM, Westwood NJ, McInnes C. Pearson RJ, et al. Among authors: fischer pm. Cell Chem Biol. 2018 Sep 20;25(9):1107-1116.e4. doi: 10.1016/j.chembiol.2018.06.001. Epub 2018 Jul 12. Cell Chem Biol. 2018. PMID: 30017915 Free article.

2

A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics.

Zheleva DI, Zhelev NZ, Fischer PM, Duff SV, Warbrick E, Blake DG, Lane DP. Zheleva DI, et al. Among authors: fischer pm. Biochemistry. 2000 Jun 27;39(25):7388-97. doi: 10.1021/bi992498r. Biochemistry. 2000. PMID: 10858286

3

Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-site: structural variants of the C-terminal Phe.

Atkinson GE, Cowan A, McInnes C, Zheleva DI, Fischer PM, Chan WC. Atkinson GE, et al. Among authors: fischer pm. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2501-5. doi: 10.1016/s0960-894x(02)00508-5. Bioorg Med Chem Lett. 2002. PMID: 12182847

4

Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A.

Zheleva DI, McInnes C, Gavine AL, Zhelev NZ, Fischer PM, Lane DP. Zheleva DI, et al. Among authors: fischer pm. J Pept Res. 2002 Nov;60(5):257-70. doi: 10.1034/j.1399-3011.2002.21014.x. J Pept Res. 2002. PMID: 12383116

5

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).

McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM, MacKenzie M, Melville J, Stewart K, Wang S, Zhelev N, Zheleva D, Lane DP. McClue SJ, et al. Among authors: fischer pm. Int J Cancer. 2002 Dec 10;102(5):463-8. doi: 10.1002/ijc.10738. Int J Cancer. 2002. PMID: 12432547

6

Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.

McInnes C, Andrews MJ, Zheleva DI, Lane DP, Fischer PM. McInnes C, et al. Among authors: fischer pm. Curr Med Chem Anticancer Agents. 2003 Jan;3(1):57-69. doi: 10.2174/1568011033353506. Curr Med Chem Anticancer Agents. 2003. PMID: 12678915 Review.

7

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Wu SY, McNae I, Kontopidis G, McClue SJ, McInnes C, Stewart KJ, Wang S, Zheleva DI, Marriage H, Lane DP, Taylor P, Fischer PM, Walkinshaw MD. Wu SY, et al. Among authors: fischer pm. Structure. 2003 Apr;11(4):399-410. doi: 10.1016/s0969-2126(03)00060-1. Structure. 2003. PMID: 12679018 Free article.

8

Cyclin-dependent kinase inhibitors.

Fischer PM, Endicott J, Meijer L. Fischer PM, et al. Prog Cell Cycle Res. 2003;5:235-48. Prog Cell Cycle Res. 2003. PMID: 14593718 Review.

9

Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.

Kontopidis G, Andrews MJ, McInnes C, Cowan A, Powers H, Innes L, Plater A, Griffiths G, Paterson D, Zheleva DI, Lane DP, Green S, Walkinshaw MD, Fischer PM. Kontopidis G, et al. Among authors: fischer pm. Structure. 2003 Dec;11(12):1537-46. doi: 10.1016/j.str.2003.11.006. Structure. 2003. PMID: 14656438 Free article.

10

CDK versus GSK-3 inhibition: a purple haze no longer?

Fischer PM. Fischer PM. Chem Biol. 2003 Dec;10(12):1144-6. doi: 10.1016/j.chembiol.2003.12.009. Chem Biol. 2003. PMID: 14700620

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