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The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU. Jensen DD, et al. Among authors: canals m. J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1. J Biol Chem. 2013. PMID: 23818521 Free PMC article.
Novel GPCR paradigms at the μ-opioid receptor.
Thompson GL, Kelly E, Christopoulos A, Canals M. Thompson GL, et al. Among authors: canals m. Br J Pharmacol. 2015 Jan;172(2):287-96. doi: 10.1111/bph.12600. Epub 2014 Jul 1. Br J Pharmacol. 2015. PMID: 24460711 Free PMC article. Review.
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW. Jensen DD, et al. Among authors: canals m. Sci Transl Med. 2017 May 31;9(392):eaal3447. doi: 10.1126/scitranslmed.aal3447. Sci Transl Med. 2017. PMID: 28566424 Free PMC article.
316 results