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Page 1
Smac mimetics and innate immune stimuli synergize to promote tumor death.
Beug ST, Tang VA, LaCasse EC, Cheung HH, Beauregard CE, Brun J, Nuyens JP, Earl N, St-Jean M, Holbrook J, Dastidar H, Mahoney DJ, Ilkow C, Le Boeuf F, Bell JC, Korneluk RG. Beug ST, et al. Among authors: earl n. Nat Biotechnol. 2014 Feb;32(2):182-90. doi: 10.1038/nbt.2806. Epub 2014 Jan 26. Nat Biotechnol. 2014. PMID: 24463573 Free PMC article.
Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis.
Moore CS, Earl N, Frenette R, Styhler A, Mancini JA, Nicholson DW, Hebb AL, Owens T, Robertson GS. Moore CS, et al. Among authors: earl n. J Pharmacol Exp Ther. 2006 Oct;319(1):63-72. doi: 10.1124/jpet.106.106096. Epub 2006 Jun 29. J Pharmacol Exp Ther. 2006. PMID: 16809479 Free article.
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