Scholze P - Search Results

1

SAR-Guided Scoring Function and Mutational Validation Reveal the Binding Mode of CGS-8216 at the α1+/γ2- Benzodiazepine Site.

Siebert DCB, Wieder M, Schlener L, Scholze P, Boresch S, Langer T, Schnürch M, Mihovilovic MD, Richter L, Ernst M, Ecker GF. Siebert DCB, et al. Among authors: scholze p. J Chem Inf Model. 2018 Aug 27;58(8):1682-1696. doi: 10.1021/acs.jcim.8b00199. Epub 2018 Aug 8. J Chem Inf Model. 2018. PMID: 30028134

2

Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.

Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M. Mirheydari P, et al. Among authors: scholze p. Neurochem Res. 2014 Jun;39(6):1057-1067. doi: 10.1007/s11064-013-1156-3. Epub 2013 Sep 26. Neurochem Res. 2014. PMID: 24072672 Free PMC article.

3

Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABA_A receptors containing the α5 subunit.

Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM. Stamenić TT, et al. Among authors: scholze p. Eur J Pharmacol. 2016 Nov 15;791:433-443. doi: 10.1016/j.ejphar.2016.09.016. Epub 2016 Sep 14. Eur J Pharmacol. 2016. PMID: 27639297 Free PMC article.

4

Molecular tools for GABA_A receptors: High affinity ligands for β1-containing subtypes.

Simeone X, Siebert DCB, Bampali K, Varagic Z, Treven M, Rehman S, Pyszkowski J, Holzinger R, Steudle F, Scholze P, Mihovilovic MD, Schnürch M, Ernst M. Simeone X, et al. Among authors: scholze p. Sci Rep. 2017 Jul 18;7(1):5674. doi: 10.1038/s41598-017-05757-4. Sci Rep. 2017. PMID: 28720884 Free PMC article.

5

Towards functional selectivity for α6β3γ2 GABA_A receptors: a series of novel pyrazoloquinolinones.

Treven M, Siebert DCB, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M, Mihovilovic MD, Ernst M. Treven M, et al. Among authors: scholze p. Br J Pharmacol. 2018 Feb;175(3):419-428. doi: 10.1111/bph.14087. Epub 2017 Dec 22. Br J Pharmacol. 2018. PMID: 29127702 Free PMC article.

6

Different Benzodiazepines Bind with Distinct Binding Modes to GABA_A Receptors.

Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P. Elgarf AA, et al. Among authors: scholze p. ACS Chem Biol. 2018 Aug 17;13(8):2033-2039. doi: 10.1021/acschembio.8b00144. Epub 2018 Jul 23. ACS Chem Biol. 2018. PMID: 29767950 Free PMC article.

7

Attaining in vivo selectivity of positive modulation of α3βγ2 GABA_A receptors in rats: A hard task!

Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM. Batinić B, et al. Among authors: scholze p. Eur Neuropsychopharmacol. 2018 Aug;28(8):903-914. doi: 10.1016/j.euroneuro.2018.05.014. Epub 2018 Jun 19. Eur Neuropsychopharmacol. 2018. PMID: 29891214

8

Engineered Flumazenil Recognition Site Provides Mechanistic Insight Governing Benzodiazepine Modulation in GABA_A Receptors.

Siebert DCB, Bampali K, Puthenkalam R, Varagic Z, Sarto-Jackson I, Scholze P, Sieghart W, Mihovilovic MD, Schnürch M, Ernst M. Siebert DCB, et al. Among authors: scholze p. ACS Chem Biol. 2018 Aug 17;13(8):2040-2047. doi: 10.1021/acschembio.8b00145. Epub 2018 Jul 23. ACS Chem Biol. 2018. PMID: 29989390

9

Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA_A receptors.

Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Vasović D, et al. Among authors: scholze p. Eur J Pain. 2019 May;23(5):973-984. doi: 10.1002/ejp.1365. Epub 2019 Feb 4. Eur J Pain. 2019. PMID: 30633839 Free PMC article.

10

GABA_A Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain-Can the Promiscuity Code Be Cracked?

Iorio MT, Vogel FD, Koniuszewski F, Scholze P, Rehman S, Simeone X, Schnürch M, Mihovilovic MD, Ernst M. Iorio MT, et al. Among authors: scholze p. Int J Mol Sci. 2020 Jan 3;21(1):334. doi: 10.3390/ijms21010334. Int J Mol Sci. 2020. PMID: 31947863 Free PMC article.

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