Carlson TJ - Search Results

1

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin.

Grillo MP, Erve JCL, Dick R, Driscoll JP, Haste N, Markova S, Brun P, Carlson TJ, Evanchik M. Grillo MP, et al. Among authors: carlson tj. Xenobiotica. 2019 Jun;49(6):718-733. doi: 10.1080/00498254.2018.1495856. Epub 2018 Oct 1. Xenobiotica. 2019. PMID: 30044681

2

Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.

Grillo MP, Markova S, Evanchik M, Trellu M, Moliner P, Brun P, Perreard-Dumaine A, Vicat P, Driscoll JP, Carlson TJ. Grillo MP, et al. Among authors: carlson tj. Xenobiotica. 2021 Feb;51(2):222-238. doi: 10.1080/00498254.2020.1839982. Epub 2020 Nov 16. Xenobiotica. 2021. PMID: 33078965

3

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †.

Yadav AS, Shah NR, Carlson TJ, Driscoll JP. Yadav AS, et al. Among authors: carlson tj. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. doi: 10.1021/acs.chemrestox.9b00268. Epub 2019 Dec 23. Chem Res Toxicol. 2020. PMID: 31815452

4

Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.

Wehn PM, Harrington PE, Carlson TJ, Davis J, Deprez P, Fotsch CH, Grillo MP, Lu JY, Morony S, Pattabiraman K, Poon SF, Reagan JD, St Jean DJ Jr, Temal T, Wang M, Yang Y, Henley C 3rd, Lively SE. Wehn PM, et al. Among authors: carlson tj. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6625-8. doi: 10.1016/j.bmcl.2013.10.050. Epub 2013 Oct 31. Bioorg Med Chem Lett. 2013. PMID: 24215889

5

Application of DBS sampling in combination with LC-MS/MS for pharmacokinetic evaluation of a compound with species-specific blood-to-plasma partitioning.

Xu G, Chen JS, Phadnis R, Huang T, Uyeda C, Soto M, Stouch B, Wells MC, James CA, Carlson TJ. Xu G, et al. Among authors: carlson tj. Bioanalysis. 2012 Aug;4(16):2037-47. doi: 10.4155/bio.12.167. Bioanalysis. 2012. PMID: 22946919

6

Recent advances in high throughput screening for ADME properties.

Carlson TJ, Fisher MB. Carlson TJ, et al. Comb Chem High Throughput Screen. 2008 Mar;11(3):258-64. doi: 10.2174/138620708783877717. Comb Chem High Throughput Screen. 2008. PMID: 18336218 Review.

7

MS(M), an efficient workflow for metabolite identification using hybrid linear ion trap Orbitrap mass spectrometer.

Cho R, Huang Y, Schwartz JC, Chen Y, Carlson TJ, Ma J. Cho R, et al. Among authors: carlson tj. J Am Soc Mass Spectrom. 2012 May;23(5):880-8. doi: 10.1007/s13361-012-0351-9. Epub 2012 Feb 14. J Am Soc Mass Spectrom. 2012. PMID: 22351295

8

Reagent-free LC-MS/MS-based pharmacokinetic quantification of polyhistidine-tagged therapeutic proteins.

Shi J, Wong JM, Ma J, Dickerson T, Hall C, Rock DA, Carlson TJ. Shi J, et al. Among authors: carlson tj. Bioanalysis. 2017 Feb;9(3):251-264. doi: 10.4155/bio-2016-0126. Epub 2017 Jan 18. Bioanalysis. 2017. PMID: 28097886

9

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

Li Z, Wang X, Eksterowicz J, Gribble MW Jr, Alba GQ, Ayres M, Carlson TJ, Chen A, Chen X, Cho R, Connors RV, DeGraffenreid M, Deignan JT, Duquette J, Fan P, Fisher B, Fu J, Huard JN, Kaizerman J, Keegan KS, Li C, Li K, Li Y, Liang L, Liu W, Lively SE, Lo MC, Ma J, McMinn DL, Mihalic JT, Modi K, Ngo R, Pattabiraman K, Piper DE, Queva C, Ragains ML, Suchomel J, Thibault S, Walker N, Wang X, Wang Z, Wanska M, Wehn PM, Weidner MF, Zhang AJ, Zhao X, Kamb A, Wickramasinghe D, Dai K, McGee LR, Medina JC. Li Z, et al. Among authors: carlson tj. J Med Chem. 2014 Apr 24;57(8):3430-49. doi: 10.1021/jm500118j. Epub 2014 Apr 2. J Med Chem. 2014. PMID: 24641103

10

Development of a robust and sensitive LC-MS/MS method for the determination of adenine in plasma of different species and its application to in vivo studies.

Shi J, Liu HF, Wong JM, Huang RN, Jones E, Carlson TJ. Shi J, et al. Among authors: carlson tj. J Pharm Biomed Anal. 2011 Dec 5;56(4):778-84. doi: 10.1016/j.jpba.2011.07.023. Epub 2011 Jul 27. J Pharm Biomed Anal. 2011. PMID: 21840665

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