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Synthesis, assignment of absolute configuration, and receptor binding studies relevant to the neuroleptic activities of a series of chiral 3-substituted cyproheptadine atropisomers.
Randall WC, Anderson PS, Cresson EL, Hunt CA, Lyon TF, Rittle KE, Remy DC, Springer JP, Hirshfield JM, Hoogsteen K, Williams M, Risley EA, Totaro JA. Randall WC, et al. Among authors: hirshfield jm. J Med Chem. 1979 Oct;22(10):1222-30. doi: 10.1021/jm00196a014. J Med Chem. 1979. PMID: 41950 No abstract available.
Inhibition of porcine kidney "enkephalinase" by substituted-N-carboxymethyl dipeptides.
Mumford RA, Zimmerman M, ten Broeke J, Taub D, Joshua H, Rothrock JW, Hirshfield JM, Springer JP, Patchett AA. Mumford RA, et al. Among authors: hirshfield jm. Biochem Biophys Res Commun. 1982 Dec 31;109(4):1303-9. doi: 10.1016/0006-291x(82)91919-2. Biochem Biophys Res Commun. 1982. PMID: 6762880 No abstract available.
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers-Schonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J. Alberts AW, et al. Among authors: hirshfield j. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61. doi: 10.1073/pnas.77.7.3957. Proc Natl Acad Sci U S A. 1980. PMID: 6933445 Free PMC article.
Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.
Lumma WC Jr, Anderson PS, Baldwin JJ, Bolhofer WA, Habecker CN, Hirshfield JM, Pietruszkiewicz AM, Randall WC, Torchiana ML, Britcher SF, Clineschmidt BV, Denny GH, Hirschmann R, Hoffman MJ, Phillips BT, Streeter KB. Lumma WC Jr, et al. Among authors: hirshfield jm. J Med Chem. 1982 Mar;25(3):207-10. doi: 10.1021/jm00345a002. J Med Chem. 1982. PMID: 6121913 No abstract available.
35 results