Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.
Zhao K, Jia Y, Peng J, Pang C, Zhang T, Han W, Jiang J, Lu X, Zhu J, Qian Y.
Zhao K, et al. Among authors: zhang t.
FASEB J. 2019 Aug;33(8):9100-9115. doi: 10.1096/fj.201802575RR. Epub 2019 May 3.
FASEB J. 2019.
PMID: 31050917
Mechanistically, anacardic acid disrupts the phosphorylation of TGF-beta activated kinase 1 and subsequently suppresses multiple receptor activator of NF-kappaB ligand-induced signaling cascades, ultimately inhibiting the induction and activation of the crucial osteoclast transcr …
Mechanistically, anacardic acid disrupts the phosphorylation of TGF-beta activated kinase 1 and subsequently suppresses multiple receptor ac …