Zhou Z - Search Results

1

Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.

Wang Z, Kang D, Chen M, Wu G, Feng D, Zhao T, Zhou Z, Huo Z, Jing L, Zuo X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Wang Z, et al. Among authors: zhou z. Chem Biol Drug Des. 2018 Dec;92(6):2009-2021. doi: 10.1111/cbdd.13373. Epub 2018 Aug 26. Chem Biol Drug Des. 2018. PMID: 30079476

2

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Chen W, Zhan P, Rai D, De Clercq E, Pannecouque C, Balzarini J, Zhou Z, Liu H, Liu X. Chen W, et al. Among authors: zhou z. Bioorg Med Chem. 2014 Mar 15;22(6):1863-72. doi: 10.1016/j.bmc.2014.01.054. Epub 2014 Feb 6. Bioorg Med Chem. 2014. PMID: 24581546

3

Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach.

Li X, Huang B, Zhou Z, Gao P, Pannecouque C, Daelemans D, De Clercq E, Zhan P, Liu X. Li X, et al. Among authors: zhou z. Chem Biol Drug Des. 2016 Aug;88(2):241-53. doi: 10.1111/cbdd.12751. Epub 2016 Mar 24. Chem Biol Drug Des. 2016. PMID: 26914186

4

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach.

Lu X, Li X, Yang J, Huang B, Kang D, Zhao F, Zhou Z, De Clercq E, Daelemans D, Pannecouque C, Zhan P, Liu X. Lu X, et al. Among authors: zhou z. Bioorg Med Chem. 2016 Sep 15;24(18):4424-4433. doi: 10.1016/j.bmc.2016.07.041. Epub 2016 Jul 21. Bioorg Med Chem. 2016. PMID: 27501911

5

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

Kang D, Fang Z, Li Z, Huang B, Zhang H, Lu X, Xu H, Zhou Z, Ding X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: zhou z. J Med Chem. 2016 Sep 8;59(17):7991-8007. doi: 10.1021/acs.jmedchem.6b00738. Epub 2016 Aug 26. J Med Chem. 2016. PMID: 27541578

6

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach.

Kang D, Zhang H, Zhou Z, Huang B, Naesens L, Zhan P, Liu X. Kang D, et al. Among authors: zhou z. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5182-5186. doi: 10.1016/j.bmcl.2016.09.071. Epub 2016 Sep 29. Bioorg Med Chem Lett. 2016. PMID: 27742238 Free PMC article.

7

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.

Li X, Gao P, Huang B, Zhou Z, Yu Z, Yuan Z, Liu H, Pannecouque C, Daelemans D, De Clercq E, Zhan P, Liu X. Li X, et al. Among authors: zhou z. Eur J Med Chem. 2017 Jan 27;126:190-201. doi: 10.1016/j.ejmech.2016.10.009. Epub 2016 Oct 5. Eur J Med Chem. 2017. PMID: 27750153

8

Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2).

Huang B, Zhou Z, Kang D, Li W, Chen Z, Zhan P, Liu X. Huang B, et al. Among authors: zhou z. Expert Opin Ther Pat. 2017 Jan;27(1):9-15. doi: 10.1080/13543776.2017.1262349. Epub 2016 Nov 25. Expert Opin Ther Pat. 2017. PMID: 27855563

9

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Zhang H, Tian Y, Kang D, Huo Z, Zhou Z, Liu H, De Clercq E, Pannecouque C, Zhan P, Liu X. Zhang H, et al. Among authors: zhou z. Eur J Med Chem. 2017 Apr 21;130:209-222. doi: 10.1016/j.ejmech.2017.02.047. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28254696

10

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Kang D, Fang Z, Huang B, Lu X, Zhang H, Xu H, Huo Z, Zhou Z, Yu Z, Meng Q, Wu G, Ding X, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: zhou z. J Med Chem. 2017 May 25;60(10):4424-4443. doi: 10.1021/acs.jmedchem.7b00332. Epub 2017 May 15. J Med Chem. 2017. PMID: 28481112

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