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Page 1
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.
Narjes F, Xue Y, von Berg S, Malmberg J, Llinas A, Olsson RI, Jirholt J, Grindebacke H, Leffler A, Hossain N, Lepistö M, Thunberg L, Leek H, Aagaard A, McPheat J, Hansson EL, Bäck E, Tångefjord S, Chen R, Xiong Y, Hongbin G, Hansson TG. Narjes F, et al. Among authors: leffler a. J Med Chem. 2018 Sep 13;61(17):7796-7813. doi: 10.1021/acs.jmedchem.8b00783. Epub 2018 Aug 27. J Med Chem. 2018. PMID: 30095900
Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ.
Olsson RI, Xue Y, von Berg S, Aagaard A, McPheat J, Hansson EL, Bernström J, Hansson P, Jirholt J, Grindebacke H, Leffler A, Chen R, Xiong Y, Ge H, Hansson TG, Narjes F. Olsson RI, et al. Among authors: leffler a. ChemMedChem. 2016 Jan 19;11(2):207-16. doi: 10.1002/cmdc.201500432. Epub 2015 Nov 10. ChemMedChem. 2016. PMID: 26553345
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
Narjes F, Llinas A, von Berg S, Jirholt J, Lever S, Pehrson R, Collins M, Malmberg A, Svanberg P, Xue Y, Olsson RI, Malmberg J, Hughes G, Hossain N, Grindebacke H, Leffler A, Krutrök N, Bäck E, Ramnegård M, Lepistö M, Thunberg L, Aagaard A, McPheat J, Hansson EL, Chen R, Xiong Y, Hansson TG. Narjes F, et al. Among authors: leffler a. J Med Chem. 2021 Sep 23;64(18):13807-13829. doi: 10.1021/acs.jmedchem.1c01197. Epub 2021 Aug 31. J Med Chem. 2021. PMID: 34464130
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.
Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A. Nilsson M, et al. Among authors: leffler a. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. doi: 10.2147/DDDT.S354291. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 36068788 Free PMC article.
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Sundqvist M, Kristensson E, Adolfsson R, Leffler A, Ahlstedt I, Engberg S, Drmota T, Sigfridsson K, Jussila R, de Verdier J, Novén A, Johansson A, Påhlman I, von Mentzer B, Lindström E. Sundqvist M, et al. Among authors: leffler a. Eur J Pharmacol. 2007 Dec 22;577(1-3):78-86. doi: 10.1016/j.ejphar.2007.08.042. Epub 2007 Sep 11. Eur J Pharmacol. 2007. PMID: 17920583
RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis.
Collins M, Pehrson R, Grindebacke H, Leffler A, Ramnegård M, Rannikmäe H, Krutrök N, Yrlid L, Pollard C, Dainty I, Narjes F, von Berg S, Llinas A, Malmberg A, McPheat J, Hansson E, Bäck E, Bernström J, Hansson TG, Keeling D, Jirholt J. Collins M, et al. Among authors: leffler a. PLoS One. 2025 Jan 16;20(1):e0317090. doi: 10.1371/journal.pone.0317090. eCollection 2025. PLoS One. 2025. PMID: 39820614
Herbivore diversity effects on Arctic tundra ecosystems: a systematic review.
Barbero-Palacios L, Barrio IC, García Criado M, Kater I, Petit Bon M, Kolari THM, Bjørkås R, Trepel J, Lundgren E, Björnsdóttir K, Hwang BC, Bartra-Cabré L, Defourneaux M, Ramsay J, Lameris TK, Leffler AJ, Lock JG, Kuoppamaa MS, Kristensen JA, Bjorkman AD, Myers-Smith I, Lecomte N, Axmacher JC, Gilg O, Den Herder M, Pagneux EP, Skarin A, Sokolova N, Windirsch T, Wheeler HC, Serrano E, Virtanen T, Hik DS, Kaarlejärvi E, Speed JDM, Soininen EM. Barbero-Palacios L, et al. Among authors: leffler aj. Environ Evid. 2024 Mar 25;13(1):6. doi: 10.1186/s13750-024-00330-9. Environ Evid. 2024. PMID: 39294685 Free PMC article.
193 results