Trujillo AS - Search Results

1

Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy.

Kronert WA, Bell KM, Viswanathan MC, Melkani GC, Trujillo AS, Huang A, Melkani A, Cammarato A, Swank DM, Bernstein SI. Kronert WA, et al. Among authors: trujillo as. Elife. 2018 Aug 13;7:e38064. doi: 10.7554/eLife.38064. Elife. 2018. PMID: 30102150 Free PMC article.

2

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. Achal M, et al. Among authors: trujillo as. J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20. J Mol Biol. 2016. PMID: 27107639 Free PMC article.

3

Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo.

Viswanathan MC, Tham RC, Kronert WA, Sarsoza F, Trujillo AS, Cammarato A, Bernstein SI. Viswanathan MC, et al. Among authors: trujillo as. Hum Mol Genet. 2017 Dec 15;26(24):4799-4813. doi: 10.1093/hmg/ddx359. Hum Mol Genet. 2017. PMID: 28973424 Free PMC article.

4

Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.

Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Trujillo AS, et al. Mol Biol Cell. 2021 Aug 19;32(18):1690-1706. doi: 10.1091/mbc.E21-02-0088. Epub 2021 Jun 3. Mol Biol Cell. 2021. PMID: 34081531 Free PMC article.

5

The R369 Myosin Residue within Loop 4 Is Critical for Actin Binding and Muscle Function in Drosophila.

Trujillo AS, Hsu KH, Viswanathan MC, Cammarato A, Bernstein SI. Trujillo AS, et al. Int J Mol Sci. 2022 Feb 25;23(5):2533. doi: 10.3390/ijms23052533. Int J Mol Sci. 2022. PMID: 35269675 Free PMC article.

6

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Melkani GC, et al. Among authors: trujillo as. PLoS Genet. 2013;9(12):e1004024. doi: 10.1371/journal.pgen.1004024. Epub 2013 Dec 19. PLoS Genet. 2013. PMID: 24367279 Free PMC article.

7

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K, Melkani GC. Trujillo AS, et al. Rare Dis. 2014 Nov 3;2(1):e968003. doi: 10.4161/2167549X.2014.968003. eCollection 2014. Rare Dis. 2014. PMID: 26942103 Free PMC article.

8

Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.

Bhide S, Trujillo AS, O'Connor MT, Young GH, Cryderman DE, Chandran S, Nikravesh M, Wallrath LL, Melkani GC. Bhide S, et al. Among authors: trujillo as. Aging Cell. 2018 Jun;17(3):e12747. doi: 10.1111/acel.12747. Epub 2018 Mar 25. Aging Cell. 2018. PMID: 29575479 Free PMC article.

9

Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.

Villanueva JE, Livelo C, Trujillo AS, Chandran S, Woodworth B, Andrade L, Le HD, Manor U, Panda S, Melkani GC. Villanueva JE, et al. Among authors: trujillo as. Nat Commun. 2019 Jun 20;10(1):2700. doi: 10.1038/s41467-019-10563-9. Nat Commun. 2019. PMID: 31221967 Free PMC article.

10

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ. Kaushik G, et al. Among authors: trujillo as. Sci Transl Med. 2015 Jun 17;7(292):292ra99. doi: 10.1126/scitranslmed.aaa5843. Sci Transl Med. 2015. PMID: 26084806 Free PMC article.

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