Elsayed MSA - Search Results

1

Synthesis of Benzo[1,6]naphthyridinones Using the Catellani Reaction.

Elsayed MSA, Griggs B, Cushman M. Elsayed MSA, et al. Org Lett. 2018 Sep 7;20(17):5228-5232. doi: 10.1021/acs.orglett.8b02171. Epub 2018 Aug 13. Org Lett. 2018. PMID: 30102543

2

Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).

Lv PC, Elsayed MS, Agama K, Marchand C, Pommier Y, Cushman M. Lv PC, et al. J Med Chem. 2016 May 26;59(10):4890-9. doi: 10.1021/acs.jmedchem.6b00220. Epub 2016 Apr 20. J Med Chem. 2016. PMID: 27097152 Free PMC article.

3

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).

Wang P, Elsayed MSA, Plescia CB, Ravji A, Redon CE, Kiselev E, Marchand C, Zeleznik O, Agama K, Pommier Y, Cushman M. Wang P, et al. Among authors: elsayed msa. J Med Chem. 2017 Apr 27;60(8):3275-3288. doi: 10.1021/acs.jmedchem.6b01565. Epub 2017 Apr 18. J Med Chem. 2017. PMID: 28418653 Free PMC article.

4

Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.

Elsayed MSA, Su Y, Wang P, Sethi T, Agama K, Ravji A, Redon CE, Kiselev E, Horzmann KA, Freeman JL, Pommier Y, Cushman M. Elsayed MSA, et al. J Med Chem. 2017 Jul 13;60(13):5364-5376. doi: 10.1021/acs.jmedchem.6b01870. Epub 2017 Jun 28. J Med Chem. 2017. PMID: 28657311 Free PMC article.

5

Synthesis of indolo[4,3-bc]phenanthridine-6,11(2H,12H)-diones using the Schiff base-homophthalic anhydride cyclization reaction.

Elsayed MSA, Zeller M, Cushman M. Elsayed MSA, et al. Synth Commun. 2016;46(23):1902-1908. doi: 10.1080/00397911.2016.1232409. Epub 2016 Sep 16. Synth Commun. 2016. PMID: 29056779 Free PMC article.

6

Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors.

Elsayed MSA, Chang S, Cushman M. Elsayed MSA, et al. Org Biomol Chem. 2017 Dec 19;16(1):108-118. doi: 10.1039/c7ob02386c. Org Biomol Chem. 2017. PMID: 29199735 Free PMC article.

7

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.

Marzi L, Agama K, Murai J, Difilippantonio S, James A, Peer CJ, Figg WD, Beck D, Elsayed MSA, Cushman M, Pommier Y. Marzi L, et al. Among authors: elsayed msa. Mol Cancer Ther. 2018 Aug;17(8):1694-1704. doi: 10.1158/1535-7163.MCT-18-0028. Epub 2018 May 10. Mol Cancer Ther. 2018. PMID: 29748210 Free PMC article.

8

Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

Elsayed MSA, Nielsen JJ, Park S, Park J, Liu Q, Kim CH, Pommier Y, Agama K, Low PS, Cushman M. Elsayed MSA, et al. J Med Chem. 2018 Dec 13;61(23):10440-10462. doi: 10.1021/acs.jmedchem.8b00510. Epub 2018 Nov 21. J Med Chem. 2018. PMID: 30460842 Free PMC article.

9

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC.

Wang KB, Elsayed MSA, Wu G, Deng N, Cushman M, Yang D. Wang KB, et al. Among authors: elsayed msa. J Am Chem Soc. 2019 Jul 17;141(28):11059-11070. doi: 10.1021/jacs.9b02679. Epub 2019 Jul 8. J Am Chem Soc. 2019. PMID: 31283877 Free PMC article.

10

Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.

Elsayed MSA, Blake JF, Boys ML, Brown E, Chapsal BD, Chicarelli MJ, Cook AW, Fell JB, Fischer JP, Hanson L, Lemieux C, Martinson MC, McCown J, McNulty OT, Mejia MJ, Neitzel NA, Otten JN, Rodriguez ME, Wilcox D, Wong CE, Zhou Y, Hinklin RJ. Elsayed MSA, et al. ACS Med Chem Lett. 2023 Nov 15;14(12):1673-1681. doi: 10.1021/acsmedchemlett.3c00310. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116446 Free PMC article.

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