Schulz-Heddergott R - Search Results

1

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM. Schulz-Heddergott R, et al. Cancer Cell. 2018 Aug 13;34(2):298-314.e7. doi: 10.1016/j.ccell.2018.07.004. Cancer Cell. 2018. PMID: 30107178 Free PMC article.

2

p53 Activity Results in DNA Replication Fork Processivity.

Klusmann I, Rodewald S, Müller L, Friedrich M, Wienken M, Li Y, Schulz-Heddergott R, Dobbelstein M. Klusmann I, et al. Cell Rep. 2016 Nov 8;17(7):1845-1857. doi: 10.1016/j.celrep.2016.10.036. Cell Rep. 2016. PMID: 27829155 Free article.

3

Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.

Kramer D, Stark N, Schulz-Heddergott R, Erytch N, Edmunds S, Roßmann L, Bastians H, Concin N, Moll UM, Dobbelstein M. Kramer D, et al. Cell Death Differ. 2017 Feb;24(2):300-316. doi: 10.1038/cdd.2016.124. Epub 2016 Nov 11. Cell Death Differ. 2017. PMID: 27834954 Free PMC article.

4

p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo.

Alexandrova EM, Mirza SA, Xu S, Schulz-Heddergott R, Marchenko ND, Moll UM. Alexandrova EM, et al. Cell Death Dis. 2017 Mar 9;8(3):e2661. doi: 10.1038/cddis.2017.80. Cell Death Dis. 2017. PMID: 28277540 Free PMC article.

5

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target.

Schulz-Heddergott R, Moll UM. Schulz-Heddergott R, et al. Cancers (Basel). 2018 Jun 7;10(6):188. doi: 10.3390/cancers10060188. Cancers (Basel). 2018. PMID: 29875343 Free PMC article. Review.

6

Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.

Kramer D, Stark N, Schulz-Heddergott R, Erytch N, Edmunds S, Roßmann L, Bastians H, Concin N, Moll UM, Dobbelstein M. Kramer D, et al. Among authors: schulz heddergott r. Cell Death Differ. 2019 Mar;26(4):780. doi: 10.1038/s41418-018-0190-8. Cell Death Differ. 2019. PMID: 30177736 Free PMC article.

7

Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer.

Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R, Conradi LC, Schulz-Heddergott R. Klemke L, et al. Among authors: schulz heddergott r. Cell Death Dis. 2021 Feb 4;12(2):155. doi: 10.1038/s41419-021-03426-z. Cell Death Dis. 2021. PMID: 33542244 Free PMC article.

8

The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells.

Klemke L, Fehlau CF, Winkler N, Toboll F, Singh SK, Moll UM, Schulz-Heddergott R. Klemke L, et al. Among authors: schulz heddergott r. Front Oncol. 2021 Jun 11;11:642603. doi: 10.3389/fonc.2021.642603. eCollection 2021. Front Oncol. 2021. PMID: 34178628 Free PMC article.

9

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity.

Isermann T, Şener ÖÇ, Stender A, Klemke L, Winkler N, Neesse A, Li J, Wegwitz F, Moll UM, Schulz-Heddergott R. Isermann T, et al. Among authors: schulz heddergott r. Nat Commun. 2021 Jun 29;12(1):4019. doi: 10.1038/s41467-021-24064-1. Nat Commun. 2021. PMID: 34188043 Free PMC article.

10

CDK4/6 inhibition confers protection of normal gut epithelia against gemcitabine and the active metabolite of irinotecan.

Blume J, Claus L, Isermann T, Dickmanns A, Conradi LC, Schulz-Heddergott R, Dobbelstein M. Blume J, et al. Among authors: schulz heddergott r. Cell Cycle. 2023 Jul;22(13):1563-1582. doi: 10.1080/15384101.2023.2217003. Epub 2023 Jun 2. Cell Cycle. 2023. PMID: 37266562 Free PMC article.

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