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Food-grade titanium dioxide (E171) by solid or liquid matrix administration induces inflammation, germ cells sloughing in seminiferous tubules and blood-testis barrier disruption in mice.
Rodríguez-Escamilla JC, Medina-Reyes EI, Rodríguez-Ibarra C, Déciga-Alcaraz A, Flores-Flores JO, Ganem-Rondero A, Rodríguez-Sosa M, Terrazas LI, Delgado-Buenrostro NL, Chirino YI. Rodríguez-Escamilla JC, et al. Among authors: rodriguez ibarra c. J Appl Toxicol. 2019 Nov;39(11):1586-1605. doi: 10.1002/jat.3842. Epub 2019 Aug 15. J Appl Toxicol. 2019. PMID: 31415109
Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat diet model.
Medina-Reyes EI, Delgado-Buenrostro NL, Díaz-Urbina D, Rodríguez-Ibarra C, Déciga-Alcaraz A, González MI, Reyes JL, Villamar-Duque TE, Flores-Sánchez ML, Hernández-Pando R, Mancilla-Díaz JM, Chirino YI, Pedraza-Chaverri J. Medina-Reyes EI, et al. Among authors: rodriguez ibarra c. Food Chem Toxicol. 2020 Dec;146:111786. doi: 10.1016/j.fct.2020.111786. Epub 2020 Oct 8. Food Chem Toxicol. 2020. PMID: 33038453
Food grade titanium dioxide accumulation leads to cellular alterations in colon cells after removal of a 24-hour exposure.
Rodríguez-Ibarra C, Medina-Reyes EI, Déciga-Alcaraz A, Delgado-Buenrostro NL, Quezada-Maldonado EM, Ispanixtlahuatl-Meráz O, Ganem-Rondero A, Flores-Flores JO, Vázquez-Zapién GJ, Mata-Miranda MM, López-Marure R, Pedraza-Chaverri J, García-Cuéllar CM, Sánchez-Pérez Y, Chirino YI. Rodríguez-Ibarra C, et al. Toxicology. 2022 Aug;478:153280. doi: 10.1016/j.tox.2022.153280. Epub 2022 Aug 13. Toxicology. 2022. PMID: 35973603
Toxicity of engineered nanomaterials with different physicochemical properties and the role of protein corona on cellular uptake and intrinsic ROS production.
Déciga-Alcaraz A, Medina-Reyes EI, Delgado-Buenrostro NL, Rodríguez-Ibarra C, Ganem-Rondero A, Vázquez-Zapién GJ, Mata-Miranda MM, Limón-Pacheco JH, García-Cuéllar CM, Sánchez-Pérez Y, Chirino YI. Déciga-Alcaraz A, et al. Among authors: rodriguez ibarra c. Toxicology. 2020 Sep;442:152545. doi: 10.1016/j.tox.2020.152545. Epub 2020 Aug 2. Toxicology. 2020. PMID: 32755642
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