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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome A, Ambler CM, Arnold E, Banker ME, Brown MF, Chrencik J, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gopalsamy A, Hayward MM, Hegen M, Hollingshead BD, Jussif J, Knafels JD, Limburg DC, Lin D, Lin TH, Pierce BS, Saiah E, Sharma R, Symanowicz PT, Telliez JB, Trujillo JI, Vajdos FF, Vincent F, Wan ZK, Xing L, Yang X, Yang X, Zhang L. Fensome A, et al. Among authors: zhang l. J Med Chem. 2018 Oct 11;61(19):8597-8612. doi: 10.1021/acs.jmedchem.8b00917. Epub 2018 Aug 16. J Med Chem. 2018. PMID: 30113844
Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation.
Huang X, Roet KCD, Zhang L, Brault A, Berg AP, Jefferson AB, Klug-McLeod J, Leach KL, Vincent F, Yang H, Coyle AJ, Jones LH, Frost D, Wiskow O, Chen K, Maeda R, Grantham A, Dornon MK, Klim JR, Siekmann MT, Zhao D, Lee S, Eggan K, Woolf CJ. Huang X, et al. Among authors: zhang l. Cell Rep. 2021 Jun 8;35(10):109224. doi: 10.1016/j.celrep.2021.109224. Cell Rep. 2021. PMID: 34107252 Free PMC article.
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park H, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD. Chen JL, et al. Among authors: zhang l, zhang p. J Am Chem Soc. 2020 May 13;142(19):8706-8727. doi: 10.1021/jacs.0c00768. Epub 2020 May 4. J Am Chem Soc. 2020. PMID: 32364710 Free PMC article.
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.
Garnsey MR, Wang Y, Edmonds DJ, Sammons MF, Reidich B, Ahn Y, Ashkenazi Y, Carlo A, Cerny MA, Coffman KJ, Culver JA, Dechert Schmitt AM, Eng H, Fisher EL, Gutierrez JA, James L, Jordan S, Kohrt JT, Kramer M, LaChapelle EA, Lee JC, Lee J, Li D, Li Z, Liu S, Liu J, Magee TV, Miller MR, Moran M, Nason DM, Nedoma NL, O'Neil SV, Piotrowski MA, Racich J, Sommese RF, Stevens LM, Wright AS, Xiao J, Zhang L, Zhou D, Barrandon O, Clasquin MF. Garnsey MR, et al. Among authors: zhang l. Nat Commun. 2025 Jan 2;16(1):297. doi: 10.1038/s41467-024-54487-5. Nat Commun. 2025. PMID: 39746932 Free PMC article.
AA-Stacked Hydrogen-Substituted Graphdiyne for Enhanced Lithium Storage.
Fan H, Liu Y, Chen Z, Lai C, Li X, Qu Z, Li C, Peng M, Ding F, Zhang L. Fan H, et al. Among authors: zhang l. Angew Chem Int Ed Engl. 2025 Jan 20:e202422089. doi: 10.1002/anie.202422089. Online ahead of print. Angew Chem Int Ed Engl. 2025. PMID: 39831788
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