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Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB.
Kim J, Flood JJ, Kristofich MR, Gidfar C, Morgenthaler AB, Fuhrer T, Sauer U, Snyder D, Cooper VS, Ebmeier CC, Old WM, Copley SD. Kim J, et al. Among authors: copley sd. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24164-24173. doi: 10.1073/pnas.1915569116. Epub 2019 Nov 11. Proc Natl Acad Sci U S A. 2019. PMID: 31712440 Free PMC article.
Setting the stage for evolution of a new enzyme.
Copley SD. Copley SD. Curr Opin Struct Biol. 2021 Aug;69:41-49. doi: 10.1016/j.sbi.2021.03.001. Epub 2021 Apr 14. Curr Opin Struct Biol. 2021. PMID: 33865035 Free PMC article. Review.
68 results