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914 results

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Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.
Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, Trojanowski JQ. Brettschneider J, et al. Among authors: lee vm, lee eb. Neuropathol Appl Neurobiol. 2017 Jun;43(4):315-329. doi: 10.1111/nan.12362. Epub 2016 Oct 18. Neuropathol Appl Neurobiol. 2017. PMID: 27716988 Free PMC article.
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.
Coughlin DG, Ittyerah R, Peterson C, Phillips JS, Miller S, Rascovsky K, Weintraub D, Siderowf AD, Duda JE, Hurtig HI, Wolk DA, McMillan CT, Yushkevich PA, Grossman M, Lee EB, Trojanowski JQ, Irwin DJ. Coughlin DG, et al. Among authors: lee eb. Neuropathol Appl Neurobiol. 2020 Dec;46(7):707-721. doi: 10.1111/nan.12659. Epub 2020 Sep 24. Neuropathol Appl Neurobiol. 2020. PMID: 32892355 Free PMC article.
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.
Wisse LEM, Ravikumar S, Ittyerah R, Lim S, Lane J, Bedard ML, Xie L, Das SR, Schuck T, Grossman M, Lee EB, Tisdall MD, Prabhakaran K, Detre JA, Mizsei G, Trojanowski JQ, Artacho-Pérula E, de Iñiguez de Onzono Martin MM, M Arroyo-Jiménez M, Muñoz Lopez M, Molina Romero FJ, P Marcos Rabal M, Cebada Sánchez S, Delgado González JC, de la Rosa Prieto C, Córcoles Parada M, Wolk DA, Irwin DJ, Insausti R, Yushkevich PA. Wisse LEM, et al. Among authors: lee eb. Acta Neuropathol Commun. 2021 Jul 21;9(1):128. doi: 10.1186/s40478-021-01225-3. Acta Neuropathol Commun. 2021. PMID: 34289895 Free PMC article.
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease.
Šušnjar U, Škrabar N, Brown AL, Abbassi Y, Phatnani H; NYGC ALS Consortium; Cortese A, Cereda C, Bugiardini E, Cardani R, Meola G, Ripolone M, Moggio M, Romano M, Secrier M, Fratta P, Buratti E. Šušnjar U, et al. Commun Biol. 2022 Apr 5;5(1):314. doi: 10.1038/s42003-022-03253-8. Commun Biol. 2022. PMID: 35383280 Free PMC article.
Pathological drivers of neurodegeneration in suspected non-Alzheimer's disease pathophysiology.
Wisse LEM, de Flores R, Xie L, Das SR, McMillan CT, Trojanowski JQ, Grossman M, Lee EB, Irwin D, Yushkevich PA, Wolk DA; Alzheimer’s Disease NeuroImaging Initiative. Wisse LEM, et al. Among authors: lee eb. Alzheimers Res Ther. 2021 May 14;13(1):100. doi: 10.1186/s13195-021-00835-2. Alzheimers Res Ther. 2021. PMID: 33990226 Free PMC article.
Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies.
Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, Ethier E, Strom R, Zanella CA, Nithianandam V, Ritter D, Henderson A, Saurat N, Afroz J, Nutter-Upham A, Benyamini H, Copty J, Ravishankar S, Morrow A, Mitchel J, Neavin D, Gupta R, Farbehi N, Grundman J, Myers RH, Scherzer CR, Trojanowski JQ, Van Deerlin VM, Cooper AA, Lee EB, Erlich Y, Lindquist S, Peng J, Geschwind DH, Powell J, Studer L, Feany MB, Sunyaev SR, Khurana V. Nazeen S, et al. Among authors: lee eb. bioRxiv [Preprint]. 2024 Mar 7:2024.03.03.583145. doi: 10.1101/2024.03.03.583145. bioRxiv. 2024. PMID: 38496508 Free PMC article. Preprint.
C9orf72 repeat expansions modify risk for secondary motor and cognitive-behavioral symptoms in behavioral-variant frontotemporal degeneration and amyotrophic lateral sclerosis.
Spencer BE, Xie SX, Elman L, Quinn CC, Amado D, Baer M, Lee EB, Van Deerlin VM, Dratch L, Massimo L, Irwin DJ, McMillan CT. Spencer BE, et al. Among authors: lee eb. medRxiv [Preprint]. 2024 Sep 19:2024.04.30.24306638. doi: 10.1101/2024.04.30.24306638. medRxiv. 2024. PMID: 38746326 Free PMC article. Preprint.
Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance.
Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Lee EB. Phan JM, et al. Among authors: lee eb. bioRxiv [Preprint]. 2023 Mar 15:2023.03.15.532082. doi: 10.1101/2023.03.15.532082. bioRxiv. 2023. Update in: J Clin Invest. 2024 May 23;134(14):e169039. doi: 10.1172/JCI169039 PMID: 36993559 Free PMC article. Updated. Preprint.
914 results