Blazer LL - Search Results

1

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.

Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS. Pavlovic Z, et al. Among authors: blazer ll. MAbs. 2018 Nov-Dec;10(8):1157-1167. doi: 10.1080/19420862.2018.1515565. Epub 2018 Sep 25. MAbs. 2018. PMID: 30183492 Free PMC article.

2

Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models.

Newsted D, Banerjee S, Watt K, Nersesian S, Truesdell P, Blazer LL, Cardarelli L, Adams JJ, Sidhu SS, Craig AW. Newsted D, et al. Among authors: blazer ll. Oncoimmunology. 2018 Nov 20;8(2):e1539613. doi: 10.1080/2162402X.2018.1539613. eCollection 2019. Oncoimmunology. 2018. PMID: 30713798 Free PMC article.

3

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. Tao Y, et al. Elife. 2019 Aug 27;8:e46134. doi: 10.7554/eLife.46134. Elife. 2019. PMID: 31452509 Free PMC article.

4

A phage-displayed single-chain Fab library optimized for rapid production of single-chain IgGs.

Hanna R, Cardarelli L, Patel N, Blazer LL, Adams JJ, Sidhu SS. Hanna R, et al. Among authors: blazer ll. Protein Sci. 2020 Oct;29(10):2075-2084. doi: 10.1002/pro.3931. Epub 2020 Sep 15. Protein Sci. 2020. PMID: 32803886 Free PMC article.

5

Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins.

Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS. Gallo E, et al. J Mol Biol. 2021 Jul 23;433(15):167090. doi: 10.1016/j.jmb.2021.167090. Epub 2021 Jun 4. J Mol Biol. 2021. PMID: 34090922

6

A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.

Chidiac R, Abedin M, Macleod G, Yang A, Thibeault PE, Blazer LL, Adams JJ, Zhang L, Roehrich H, Jo HN, Seshagiri S, Sidhu SS, Junge HJ, Angers S. Chidiac R, et al. Among authors: blazer ll. EMBO Mol Med. 2021 Jul 7;13(7):e13977. doi: 10.15252/emmm.202113977. Epub 2021 Jun 9. EMBO Mol Med. 2021. PMID: 34105895 Free PMC article.

7

A T cell redirection platform for co-targeting dual antigens on solid tumors.

Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. Enderle L, et al. Among authors: blazer ll. MAbs. 2021 Jan-Dec;13(1):1933690. doi: 10.1080/19420862.2021.1933690. MAbs. 2021. PMID: 34190031 Free PMC article.

8

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.

Miersch S, Li Z, Saberianfar R, Ustav M, Brett Case J, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Garcia Perez J, Subramania S, Singh S, Ploder L, Ganaie S, Chen RE, Leung DW, Pandolfi PP, Novelli G, Matusali G, Colavita F, Capobianchi MR, Jain S, Gupta JB, Amarasinghe GK, Diamond MS, Rini J, Sidhu SS. Miersch S, et al. J Mol Biol. 2021 Sep 17;433(19):167177. doi: 10.1016/j.jmb.2021.167177. Epub 2021 Jul 28. J Mol Biol. 2021. PMID: 34329642 Free PMC article.

9

A Descriptor Set for Quantitative Structure-property Relationship Prediction in Biologics.

Sankar K, Trainor K, Blazer LL, Adams JJ, Sidhu SS, Day T, Meiering E, Maier JKX. Sankar K, et al. Among authors: blazer ll. Mol Inform. 2022 Sep;41(9):e2100240. doi: 10.1002/minf.202100240. Epub 2022 Mar 29. Mol Inform. 2022. PMID: 35277930

10

Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b.

Hu S, Liu S, Bian Y, Poddar M, Singh S, Cao C, McGaughey J, Bell A, Blazer LL, Adams JJ, Sidhu SS, Angers S, Monga SP. Hu S, et al. Among authors: blazer ll. Cell Rep Med. 2022 Oct 18;3(10):100754. doi: 10.1016/j.xcrm.2022.100754. Epub 2022 Oct 10. Cell Rep Med. 2022. PMID: 36220068 Free PMC article.

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