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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S. Mori G, et al. Among authors: lane tr. Tuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016/j.tube.2018.08.004. Epub 2018 Aug 11. Tuberculosis (Edinb). 2018. PMID: 30205975
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.
Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanová J, Szádocka S, Huszár S, Palčeková Z, Manfredi M, Gosetti F, Lelièvre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR. Chiarelli LR, et al. Sci Rep. 2018 Feb 16;8(1):3187. doi: 10.1038/s41598-018-21614-4. Sci Rep. 2018. PMID: 29453370 Free PMC article.
Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads.
Anantpadma M, Lane T, Zorn KM, Lingerfelt MA, Clark AM, Freundlich JS, Davey RA, Madrid PB, Ekins S. Anantpadma M, et al. ACS Omega. 2019 Jan 31;4(1):2353-2361. doi: 10.1021/acsomega.8b02948. Epub 2019 Jan 30. ACS Omega. 2019. PMID: 30729228 Free PMC article.
Repurposing Quinacrine against Ebola Virus Infection In Vivo.
Lane TR, Comer JE, Freiberg AN, Madrid PB, Ekins S. Lane TR, et al. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01142-19. doi: 10.1128/AAC.01142-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31307979 Free PMC article.
123 results