Danhof M - Search Results

1

The future of drug development: the paradigm shift towards systems therapeutics.

Danhof M, Klein K, Stolk P, Aitken M, Leufkens H. Danhof M, et al. Drug Discov Today. 2018 Dec;23(12):1990-1995. doi: 10.1016/j.drudis.2018.09.002. Epub 2018 Sep 10. Drug Discov Today. 2018. PMID: 30213566 Free article. Review.

2

The implications of target saturation for the use of drug-target residence time.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Among authors: danhof m. Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.234. Nat Rev Drug Discov. 2018. PMID: 30591716 No abstract available.

3

Translation of drug effects from experimental models of neuropathic pain and analgesia to humans.

Taneja A, Di Iorio VL, Danhof M, Della Pasqua O. Taneja A, et al. Among authors: danhof m. Drug Discov Today. 2012 Aug;17(15-16):837-49. doi: 10.1016/j.drudis.2012.02.010. Epub 2012 Mar 3. Drug Discov Today. 2012. PMID: 22445930 Review.

4

Systems pharmacology - Towards the modeling of network interactions.

Danhof M. Danhof M. Eur J Pharm Sci. 2016 Oct 30;94:4-14. doi: 10.1016/j.ejps.2016.04.027. Epub 2016 Apr 27. Eur J Pharm Sci. 2016. PMID: 27131606 Free article. Review.

5

Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

Danhof M. Danhof M. J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):447-62. doi: 10.1007/s10928-015-9437-x. Epub 2015 Aug 30. J Pharmacokinet Pharmacodyn. 2015. PMID: 26319673 Free PMC article.

6

Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling.

Ince I, de Wildt SN, Tibboel D, Danhof M, Knibbe CA. Ince I, et al. Among authors: danhof m. Drug Discov Today. 2009 Mar;14(5-6):316-20. doi: 10.1016/j.drudis.2008.11.004. Epub 2008 Dec 26. Drug Discov Today. 2009. PMID: 19059496 Review.

7

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC. de Witte WE, et al. Among authors: danhof m. Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Expert Opin Drug Discov. 2016. PMID: 26484747 Review.

8

Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm.

Taneja A, Della Pasqua O, Danhof M. Taneja A, et al. Among authors: danhof m. Eur J Clin Pharmacol. 2017 Oct;73(10):1219-1236. doi: 10.1007/s00228-017-2301-8. Epub 2017 Sep 11. Eur J Clin Pharmacol. 2017. PMID: 28894907 Free PMC article. Review.

9

Ontogeny of hepatic glucuronidation; methods and results.

Krekels EH, Danhof M, Tibboel D, Knibbe CA. Krekels EH, et al. Among authors: danhof m. Curr Drug Metab. 2012 Jul;13(6):728-43. doi: 10.2174/138920012800840455. Curr Drug Metab. 2012. PMID: 22452455 Review.

10

Drug disposition in obesity: toward evidence-based dosing.

Knibbe CA, Brill MJ, van Rongen A, Diepstraten J, van der Graaf PH, Danhof M. Knibbe CA, et al. Among authors: danhof m. Annu Rev Pharmacol Toxicol. 2015;55:149-67. doi: 10.1146/annurev-pharmtox-010814-124354. Epub 2014 Oct 17. Annu Rev Pharmacol Toxicol. 2015. PMID: 25340929 Review.

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