Gou W - Search Results

1

Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives.

Guo M, Zuo D, Zhang J, Xing L, Gou W, Jiang F, Jiang N, Zhang D, Zhai X. Guo M, et al. Among authors: gou w. Eur J Med Chem. 2018 Oct 5;158:322-333. doi: 10.1016/j.ejmech.2018.09.012. Epub 2018 Sep 6. Eur J Med Chem. 2018. PMID: 30223120

2

Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R.

Wang Y, Chen S, Hu G, Wang J, Gou W, Zuo D, Gu Y, Gong P, Zhai X. Wang Y, et al. Among authors: gou w. Eur J Med Chem. 2018 Jan 1;143:123-136. doi: 10.1016/j.ejmech.2017.11.008. Epub 2017 Nov 6. Eur J Med Chem. 2018. PMID: 29174809

3

CD74-ROS1 G2032R mutation transcriptionally up-regulates Twist1 in non-small cell lung cancer cells leading to increased migration, invasion, and resistance to crizotinib.

Gou W, Zhou X, Liu Z, Wang L, Shen J, Xu X, Li Z, Zhai X, Zuo D, Wu Y. Gou W, et al. Cancer Lett. 2018 May 28;422:19-28. doi: 10.1016/j.canlet.2018.02.032. Epub 2018 Feb 23. Cancer Lett. 2018. PMID: 29477381

4

Titanium dioxide nanoparticles induce mouse hippocampal neuron apoptosis via oxidative stress- and calcium imbalance-mediated endoplasmic reticulum stress.

He Q, Zhou X, Liu Y, Gou W, Cui J, Li Z, Wu Y, Zuo D. He Q, et al. Among authors: gou w. Environ Toxicol Pharmacol. 2018 Oct;63:6-15. doi: 10.1016/j.etap.2018.08.003. Epub 2018 Aug 10. Environ Toxicol Pharmacol. 2018. PMID: 30114659

5

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.

Zheng D, Chang X, Liu Y, Xu J, Gou W, Li Z, Zuo D, Zhang W, Wu Y. Zheng D, et al. Among authors: gou w. Cancer Biol Ther. 2019;20(4):513-523. doi: 10.1080/15384047.2018.1537578. Epub 2018 Dec 4. Cancer Biol Ther. 2019. PMID: 30514153 Free PMC article.

6

Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca²⁺ Imbalance-Mediated Endoplasmic Reticulum Stress.

Cui J, Liu Y, Chang X, Gou W, Zhou X, Liu Z, Li Z, Wu Y, Zuo D. Cui J, et al. Among authors: gou w. Oxid Med Cell Longev. 2019 Jan 9;2019:2593742. doi: 10.1155/2019/2593742. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30728884 Free PMC article.

7

Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.

Wei H, Duan Y, Gou W, Cui J, Ning H, Li D, Qin Y, Liu Q, Li Y. Wei H, et al. Among authors: gou w. Eur J Med Chem. 2019 Nov 1;181:111552. doi: 10.1016/j.ejmech.2019.07.055. Epub 2019 Jul 24. Eur J Med Chem. 2019. PMID: 31387063

8

ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.

Gou W, Li Z, Xu X, Shen J, Guo M, Zhou X, Zhang X, Wu Y, Zhai X, Zuo D. Gou W, et al. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118712. doi: 10.1016/j.bbamcr.2020.118712. Epub 2020 Mar 26. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 32224191 Free article.

9

Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2.

Yu J, Luo L, Hu T, Cui Y, Sun X, Gou W, Hou W, Li Y, Sun T. Yu J, et al. Among authors: gou w. Eur J Med Chem. 2022 Jan 5;227:113898. doi: 10.1016/j.ejmech.2021.113898. Epub 2021 Oct 9. Eur J Med Chem. 2022. PMID: 34656898

10

Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.

Wei H, Guo J, Sun X, Gou W, Ning H, Fang Z, Liu Q, Hou W, Li Y. Wei H, et al. Among authors: gou w. Eur J Med Chem. 2022 Jan 5;227:113918. doi: 10.1016/j.ejmech.2021.113918. Epub 2021 Oct 14. Eur J Med Chem. 2022. PMID: 34688014

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