Guo M - Search Results

1

Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives.

Guo M, Zuo D, Zhang J, Xing L, Gou W, Jiang F, Jiang N, Zhang D, Zhai X. Guo M, et al. Eur J Med Chem. 2018 Oct 5;158:322-333. doi: 10.1016/j.ejmech.2018.09.012. Epub 2018 Sep 6. Eur J Med Chem. 2018. PMID: 30223120

2

Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors.

Wang X, Jiang N, Zhao S, Xi S, Wang J, Jing T, Zhang W, Guo M, Gong P, Zhai X. Wang X, et al. Among authors: guo m. Bioorg Med Chem. 2017 Feb 1;25(3):886-896. doi: 10.1016/j.bmc.2016.12.002. Epub 2016 Dec 12. Bioorg Med Chem. 2017. PMID: 28011202

3

Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development.

Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, Guo M, Yang D, Wang S. Aguilar A, et al. Among authors: guo m. J Med Chem. 2017 Apr 13;60(7):2819-2839. doi: 10.1021/acs.jmedchem.6b01665. Epub 2017 Mar 24. J Med Chem. 2017. PMID: 28339198 Free PMC article.

4

Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents.

Liu J, Zuo D, Jing T, Guo M, Xing L, Zhang W, Zhao J, Shen J, Gong P, Zhang D, Zhai X. Liu J, et al. Among authors: guo m. Bioorg Med Chem. 2017 Aug 1;25(15):4088-4099. doi: 10.1016/j.bmc.2017.05.057. Epub 2017 May 30. Bioorg Med Chem. 2017. PMID: 28622907

5

Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors.

Jing T, Miao X, Jiang F, Guo M, Xing L, Zhang J, Zuo D, Lei H, Zhai X. Jing T, et al. Among authors: guo m. Bioorg Med Chem. 2018 May 1;26(8):1784-1796. doi: 10.1016/j.bmc.2018.02.023. Epub 2018 Feb 21. Bioorg Med Chem. 2018. PMID: 29496411

6

Design, synthesis and biological evaluation N²-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives bearing acylamino or DBTD 'head' as potential ALK inhibitors.

Xing L, Jing T, Zhang J, Guo M, Miao X, Jiang F, Zhai X. Xing L, et al. Among authors: guo m. Bioorg Chem. 2018 Dec;81:689-699. doi: 10.1016/j.bioorg.2018.09.019. Epub 2018 Sep 12. Bioorg Chem. 2018. PMID: 30268049

7

Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties.

Lei H, Jiang N, Miao X, Xing L, Guo M, Liu Y, Xu H, Gong P, Zuo D, Zhai X. Lei H, et al. Among authors: guo m. Eur J Med Chem. 2019 Jun 1;171:297-309. doi: 10.1016/j.ejmech.2019.03.038. Epub 2019 Mar 23. Eur J Med Chem. 2019. PMID: 30927566

8

An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects.

Lei H, Jia F, Cao M, Wang J, Guo M, Zhu M, Zuo D, Zhai X. Lei H, et al. Among authors: guo m. Bioorg Med Chem. 2019 Oct 15;27(20):115051. doi: 10.1016/j.bmc.2019.115051. Epub 2019 Aug 21. Bioorg Med Chem. 2019. PMID: 31492532

9

Design, synthesis and biological evaluation of 2-arylaminopyrimidine derivatives bearing 1,3,8-triazaspiro[4,5]decan-4-one or piperidine-3-carboxamide moiety as novel Type-I^1/2 ALK inhibitors.

Miao X, Xing L, Guo M, Zhang H, Liu S, Yin S, Gong P, Zhang D, Zhai X. Miao X, et al. Among authors: guo m. Bioorg Chem. 2020 Jan;94:103456. doi: 10.1016/j.bioorg.2019.103456. Epub 2019 Nov 21. Bioorg Chem. 2020. PMID: 31787343

10

Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.

Jiang N, Zhou Y, Zhu M, Zhang J, Cao M, Lei H, Guo M, Gong P, Su G, Zhai X. Jiang N, et al. Among authors: guo m. Eur J Med Chem. 2020 Feb 1;187:111904. doi: 10.1016/j.ejmech.2019.111904. Epub 2019 Nov 19. Eur J Med Chem. 2020. PMID: 31806537

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