Almenara J - Search Results

1

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263.

Dastur A, Choi A, Costa C, Yin X, Williams A, McClanaghan J, Greenberg M, Roderick J, Patel NU, Boisvert J, McDermott U, Garnett MJ, Almenara J, Grant S, Rizzo K, Engelman JA, Kelliher M, Faber AC, Benes CH. Dastur A, et al. Among authors: almenara j. Clin Cancer Res. 2019 Jan 1;25(1):312-324. doi: 10.1158/1078-0432.CCR-18-0867. Epub 2018 Sep 17. Clin Cancer Res. 2019. PMID: 30224339 Free PMC article.

2

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

Rosato RR, Almenara JA, Grant S. Rosato RR, et al. Cancer Res. 2003 Jul 1;63(13):3637-45. Cancer Res. 2003. PMID: 12839953

3

The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation.

Rosato RR, Almenara JA, Coe S, Grant S. Rosato RR, et al. Cancer Res. 2007 Oct 1;67(19):9490-500. doi: 10.1158/0008-5472.CAN-07-0598. Cancer Res. 2007. PMID: 17909059

4

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.

Yu C, Rahmani M, Almenara J, Subler M, Krystal G, Conrad D, Varticovski L, Dent P, Grant S. Yu C, et al. Among authors: almenara j. Cancer Res. 2003 May 1;63(9):2118-26. Cancer Res. 2003. PMID: 12727828

5

Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.

Dasmahapatra G, Almenara JA, Grant S. Dasmahapatra G, et al. Mol Pharmacol. 2006 Jan;69(1):288-98. doi: 10.1124/mol.105.016154. Epub 2005 Oct 11. Mol Pharmacol. 2006. Retraction in: Mol Pharmacol. 2019 Apr;95(4):335. doi: 10.1124/mol.105.016154retraction PMID: 16219908 Retracted.

6

Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.

Rosato RR, Almenara JA, Dai Y, Grant S. Rosato RR, et al. Mol Cancer Ther. 2003 Dec;2(12):1273-84. Mol Cancer Ther. 2003. PMID: 14707268

7

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.

Rosato RR, Almenara JA, Kolla SS, Maggio SC, Coe S, Giménez MS, Dent P, Grant S. Rosato RR, et al. Mol Cancer Ther. 2007 Feb;6(2):692-702. doi: 10.1158/1535-7163.MCT-06-0562. Mol Cancer Ther. 2007. PMID: 17308065

8

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

Dai Y, Chen S, Shah R, Pei XY, Wang L, Almenara JA, Kramer LB, Dent P, Grant S. Dai Y, et al. Blood. 2011 Feb 10;117(6):1947-57. doi: 10.1182/blood-2010-06-291146. Epub 2010 Dec 10. Blood. 2011. PMID: 21148814 Free PMC article.

9

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

Almenara J, Rosato R, Grant S. Almenara J, et al. Leukemia. 2002 Jul;16(7):1331-43. doi: 10.1038/sj.leu.2402535. Leukemia. 2002. PMID: 12094258

10

The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.

Rosato RR, Almenara JA, Cartee L, Betts V, Chellappan SP, Grant S. Rosato RR, et al. Mol Cancer Ther. 2002 Feb;1(4):253-66. Mol Cancer Ther. 2002. PMID: 12467221

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