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Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Essig K, Kronbeck N, Guimaraes JC, Lohs C, Schlundt A, Hoffmann A, Behrens G, Brenner S, Kowalska J, Lopez-Rodriguez C, Jemielity J, Holtmann H, Reiche K, Hackermüller J, Sattler M, Zavolan M, Heissmeyer V. Essig K, et al. Among authors: jemielity j. Nat Commun. 2018 Sep 19;9(1):3810. doi: 10.1038/s41467-018-06184-3. Nat Commun. 2018. PMID: 30232334 Free PMC article.
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M. Zmudzinski M, et al. Among authors: jemielity j. Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w. Sci Rep. 2023. PMID: 37280236 Free PMC article.
Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.
Kowalska J, Lewdorowicz M, Zuberek J, Grudzien-Nogalska E, Bojarska E, Stepinski J, Rhoads RE, Darzynkiewicz E, Davis RE, Jemielity J. Kowalska J, et al. Among authors: jemielity j. RNA. 2008 Jun;14(6):1119-31. doi: 10.1261/rna.990208. Epub 2008 Apr 22. RNA. 2008. PMID: 18430890 Free PMC article.
m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation.
Kowalska J, Lukaszewicz M, Zuberek J, Ziemniak M, Strenkowska M, Darzynkiewicz E, Jemielity J. Kowalska J, et al. Among authors: jemielity j. Nucleic Acids Symp Ser (Oxf). 2008;(52):291-2. doi: 10.1093/nass/nrn147. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776368
138 results