Zeng L - Search Results

1

N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.

Yu X, Cheng G, Zhang L, Zhang Y, Wang Q, Zhao M, Zeng L, Hu Y, Feng L. Yu X, et al. Among authors: zeng l. Sci Rep. 2018 Sep 19;8(1):14040. doi: 10.1038/s41598-018-32326-0. Sci Rep. 2018. PMID: 30232349 Free PMC article.

2

Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice.

Zeng HL, Huang SL, Xie FC, Zeng LM, Hu YH, Leng Y. Zeng HL, et al. Acta Pharmacol Sin. 2015 Mar;36(3):343-52. doi: 10.1038/aps.2014.147. Acta Pharmacol Sin. 2015. PMID: 25732571 Free PMC article.

3

Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase.

Liu Y, Jin S, Peng X, Lu D, Zeng L, Sun Y, Ai J, Geng M, Hu Y. Liu Y, et al. Among authors: zeng l. Eur J Med Chem. 2016 Jan 27;108:322-333. doi: 10.1016/j.ejmech.2015.11.042. Epub 2015 Nov 30. Eur J Med Chem. 2016. PMID: 26698536

4

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis.

Huang JS, Guo BB, Wang GH, Zeng LM, Hu YH, Wang T, Wang HY. Huang JS, et al. Acta Pharmacol Sin. 2021 Feb;42(2):264-271. doi: 10.1038/s41401-020-0482-7. Epub 2020 Jul 31. Acta Pharmacol Sin. 2021. PMID: 32737468 Free PMC article.

5

Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors.

Lu D, Liu J, Zhang Y, Liu F, Zeng L, Peng R, Yang L, Ying H, Tang W, Chen W, Zuo J, Tong X, Liu T, Hu Y. Lu D, et al. Among authors: zeng l. Eur J Med Chem. 2018 Feb 10;145:328-337. doi: 10.1016/j.ejmech.2018.01.008. Epub 2018 Jan 5. Eur J Med Chem. 2018. PMID: 29335200

6

Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation.

Lu D, Liu F, Xing W, Tong X, Wang L, Wang Y, Zeng L, Feng C, Yang L, Zuo J, Hu Y. Lu D, et al. Among authors: zeng l. ACS Infect Dis. 2017 Mar 10;3(3):199-205. doi: 10.1021/acsinfecdis.6b00159. Epub 2016 Dec 29. ACS Infect Dis. 2017. PMID: 27989113

7

Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety.

Yan J, Wang G, Dang X, Guo B, Chen W, Wang T, Zeng L, Wang H, Hu Y. Yan J, et al. Among authors: zeng l. Bioorg Med Chem. 2017 Sep 1;25(17):4701-4714. doi: 10.1016/j.bmc.2017.07.007. Epub 2017 Jul 14. Bioorg Med Chem. 2017. PMID: 28739155

8

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models.

Guo DY, Li DW, Ning MM, Dang XY, Zhang LN, Zeng LM, Hu YH, Leng Y. Guo DY, et al. Biochem Biophys Res Commun. 2015 Oct 30;466(4):740-7. doi: 10.1016/j.bbrc.2015.09.130. Epub 2015 Sep 28. Biochem Biophys Res Commun. 2015. PMID: 26417688

9

A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism.

Huang JS, Guo BB, Lin FF, Zeng LM, Wang T, Dang XY, Yang Y, Hu YH, Liu J, Wang HY. Huang JS, et al. Eur J Pharm Sci. 2021 Mar 1;158:105683. doi: 10.1016/j.ejps.2020.105683. Epub 2020 Dec 19. Eur J Pharm Sci. 2021. PMID: 33347980

10

Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.

Lu D, Yan J, Wang L, Liu H, Zeng L, Zhang M, Duan W, Ji Y, Cao J, Geng M, Shen A, Hu Y. Lu D, et al. Among authors: zeng l. ACS Med Chem Lett. 2017 Jul 18;8(8):830-834. doi: 10.1021/acsmedchemlett.7b00172. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835797 Free PMC article.

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