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USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.
Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI. Fukushima T, et al. Among authors: iemura si. Biochem Biophys Res Commun. 2017 Mar 11;484(3):522-528. doi: 10.1016/j.bbrc.2017.01.101. Epub 2017 Jan 23. Biochem Biophys Res Commun. 2017. PMID: 28126338
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S. Yoshihara H, et al. Biochem Biophys Res Commun. 2012 Jun 22;423(1):122-7. doi: 10.1016/j.bbrc.2012.05.093. Epub 2012 May 23. Biochem Biophys Res Commun. 2012. PMID: 22634009
109 results