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Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy.
Arantes LA, Aguiar CJ, Amaya MJ, Figueiró NC, Andrade LM, Rocha-Resende C, Resende RR, Franchini KG, Guatimosim S, Leite MF. Arantes LA, et al. Among authors: guatimosim s. J Mol Cell Cardiol. 2012 Oct;53(4):475-86. doi: 10.1016/j.yjmcc.2012.06.017. Epub 2012 Jul 2. J Mol Cell Cardiol. 2012. PMID: 22766271
Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels.
Rocha-Resende C, Guedes de Jesus IC, Roman-Campos D, Miranda AS, Alves F, Resende RR, Dos Santos Cruz J, Machado FS, Guatimosim S. Rocha-Resende C, et al. Among authors: guatimosim s. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C478-C486. doi: 10.1152/ajpcell.00004.2016. Epub 2017 Jan 25. Am J Physiol Cell Physiol. 2017. PMID: 28122728 Free article.
Nuclear Ca2+ regulates cardiomyocyte function.
Guatimosim S, Amaya MJ, Guerra MT, Aguiar CJ, Goes AM, Gómez-Viquez NL, Rodrigues MA, Gomes DA, Martins-Cruz J, Lederer WJ, Leite MF. Guatimosim S, et al. Cell Calcium. 2008 Aug;44(2):230-42. doi: 10.1016/j.ceca.2007.11.016. Epub 2008 Jan 16. Cell Calcium. 2008. PMID: 18201761
127 results