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Page 1
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Nacson J, et al. Among authors: nussenzweig a. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. Cell Rep. 2018. PMID: 30257212 Free PMC article.
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A. Bunting SF, et al. Among authors: nussenzweig m, nussenzweig a. Cell. 2010 Apr 16;141(2):243-54. doi: 10.1016/j.cell.2010.03.012. Epub 2010 Apr 1. Cell. 2010. PMID: 20362325 Free PMC article.
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A. Bunting SF, et al. Among authors: nussenzweig a. Mol Cell. 2012 Apr 27;46(2):125-35. doi: 10.1016/j.molcel.2012.02.015. Epub 2012 Mar 22. Mol Cell. 2012. PMID: 22445484 Free PMC article.
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.
Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R. Yamane A, et al. Among authors: nussenzweig a, nussenzweig mc. Cell Rep. 2013 Jan 31;3(1):138-47. doi: 10.1016/j.celrep.2012.12.006. Epub 2013 Jan 3. Cell Rep. 2013. PMID: 23291097 Free PMC article.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. Callen E, et al. Among authors: nussenzweig a, nussenzweig mc. Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30. Cell. 2013. PMID: 23727112 Free PMC article.
More end resection is not merrier.
Zong D, Chaudhuri AR, Nussenzweig A. Zong D, et al. Among authors: nussenzweig a. Nat Struct Mol Biol. 2016 Aug 3;23(8):699-701. doi: 10.1038/nsmb.3274. Nat Struct Mol Biol. 2016. PMID: 27487392 Free PMC article.
53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1.
Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. Li M, et al. Among authors: nussenzweig a. EMBO Rep. 2016 Nov;17(11):1532-1541. doi: 10.15252/embr.201642497. Epub 2016 Sep 26. EMBO Rep. 2016. PMID: 27670884 Free PMC article.
238 results