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Neuroprotective efficacy of P7C3 compounds in primate hippocampus.
Bauman MD, Schumann CM, Carlson EL, Taylor SL, Vázquez-Rosa E, Cintrón-Pérez CJ, Shin MK, Williams NS, Pieper AA. Bauman MD, et al. Among authors: pieper aa. Transl Psychiatry. 2018 Sep 26;8(1):202. doi: 10.1038/s41398-018-0244-1. Transl Psychiatry. 2018. PMID: 30258178 Free PMC article.
Discovery of a proneurogenic, neuroprotective chemical.
Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Pieper AA, et al. Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018. Cell. 2010. PMID: 20603013 Free PMC article.
Development of proneurogenic, neuroprotective small molecules.
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. MacMillan KS, et al. Among authors: pieper aa. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6. J Am Chem Soc. 2011. PMID: 21210688 Free PMC article.
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.
Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA. Tesla R, et al. Among authors: pieper aa. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109. Epub 2012 Oct 1. Proc Natl Acad Sci U S A. 2012. PMID: 23027932 Free PMC article.
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.
De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA. De Jesús-Cortés H, et al. Among authors: pieper aa. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109. Epub 2012 Oct 1. Proc Natl Acad Sci U S A. 2012. PMID: 23027934 Free PMC article.
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.
Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM. Naidoo J, et al. Among authors: pieper aa. J Med Chem. 2014 May 8;57(9):3746-54. doi: 10.1021/jm401919s. Epub 2014 Apr 16. J Med Chem. 2014. PMID: 24697290 Free PMC article.
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM. Walker AK, et al. Among authors: pieper aa. Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22. Mol Psychiatry. 2015. PMID: 24751964 Free PMC article.
P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.
Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AA. Yin TC, et al. Among authors: pieper aa. Cell Rep. 2014 Sep 25;8(6):1731-1740. doi: 10.1016/j.celrep.2014.08.030. Epub 2014 Sep 15. Cell Rep. 2014. PMID: 25220467 Free PMC article.
Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.
Kemp SWP, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH. Kemp SWP, et al. Among authors: pieper aa. Neuroscience. 2015 Jan 22;284:202-216. doi: 10.1016/j.neuroscience.2014.10.005. Epub 2014 Oct 13. Neuroscience. 2015. PMID: 25313000
133 results