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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL. Colli ML, et al. Among authors: marchetti p. EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27. EBioMedicine. 2018. PMID: 30269996 Free PMC article.
Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.
Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P. Del Guerra S, et al. Among authors: marchetti p. Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6. doi: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr124>3.0.co;2-q. Diabetes Metab Res Rev. 2000. PMID: 10934457
Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines.
Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P. Marselli L, et al. Among authors: marchetti p. J Clin Endocrinol Metab. 2001 Oct;86(10):4974-8. doi: 10.1210/jcem.86.10.7938. J Clin Endocrinol Metab. 2001. PMID: 11600573
1,472 results