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Page 1
Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
Higuchi T, Kawaguchi K, Miyake K, Han Q, Tan Y, Oshiro H, Sugisawa N, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Chawla SP, Singh AS, Eilber FC, Singh SR, Tsuchiya H, Hoffman RM. Higuchi T, et al. Among authors: singh sr, singh as. Anticancer Res. 2018 Oct;38(10):5639-5644. doi: 10.21873/anticanres.12899. Anticancer Res. 2018. PMID: 30275182
Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models.
Kawaguchi K, Igarashi K, Miyake K, Kiyuna T, Miyake M, Singh AS, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Singh SR, Eilber FC, Hoffman RM. Kawaguchi K, et al. Among authors: singh sr, singh as. J Drug Target. 2019 Feb;27(2):211-216. doi: 10.1080/1061186X.2018.1499748. Epub 2018 Aug 23. J Drug Target. 2019. PMID: 30024282
Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model.
Kiyuna T, Tome Y, Murakami T, Kawaguchi K, Igarashi K, Miyake K, Miyake M, Li Y, Nelson SD, Dry SM, Singh AS, Russell TA, Elliott I, Singh SR, Kanaya F, Eilber FC, Hoffman RM. Kiyuna T, et al. Among authors: singh sr, singh as. BMC Cancer. 2018 Aug 20;18(1):840. doi: 10.1186/s12885-018-4703-0. BMC Cancer. 2018. PMID: 30126369 Free PMC article.
Regorafenib regressed a doxorubicin-resistant Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
Miyake K, Kiyuna T, Kawaguchi K, Higuchi T, Oshiro H, Zhang Z, Wangsiricharoen S, Razmjooei S, Li Y, Nelson SD, Murakami T, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM. Miyake K, et al. Among authors: singh sr. Cancer Chemother Pharmacol. 2019 May;83(5):809-815. doi: 10.1007/s00280-019-03782-w. Epub 2019 Feb 13. Cancer Chemother Pharmacol. 2019. PMID: 30758647
The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model.
Higuchi T, Miyake K, Sugisawa N, Oshiro H, Zhang Z, Razmjooei S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. Higuchi T, et al. Among authors: singh sr. Cancer Chemother Pharmacol. 2019 Jun;83(6):1075-1082. doi: 10.1007/s00280-019-03824-3. Epub 2019 Mar 30. Cancer Chemother Pharmacol. 2019. PMID: 30929053
The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.
Higuchi T, Sugisawa N, Yamamoto J, Oshiro H, Han Q, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Tan Y, Kuchipudi S, Bouvet M, Singh SR, Tsuchiya H, Hoffman RM. Higuchi T, et al. Among authors: singh sr. Cancer Chemother Pharmacol. 2020 Feb;85(2):285-291. doi: 10.1007/s00280-019-03986-0. Epub 2019 Nov 8. Cancer Chemother Pharmacol. 2020. PMID: 31705268
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: singh sr, singh as. Cancer Lett. 2018 Mar 28;417:168-173. doi: 10.1016/j.canlet.2017.12.028. Epub 2018 Jan 3. Cancer Lett. 2018. PMID: 29306021
Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models.
Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: singh sr, singh as. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1055-1061. doi: 10.1016/j.bbrc.2018.02.174. Epub 2018 Feb 23. Biochem Biophys Res Commun. 2018. PMID: 29481803
MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model.
Kawaguchi K, Igarashi K, Miyake K, Lwin TM, Miyake M, Kiyuna T, Hwang HK, Murakami T, Delong JC, Singh SR, Clary B, Bouvet M, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: singh sr. Tissue Cell. 2018 Jun;52:124-128. doi: 10.1016/j.tice.2018.05.003. Epub 2018 May 5. Tissue Cell. 2018. PMID: 29857821
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: singh sr. Cancer Lett. 2018 Sep 28;432:251-259. doi: 10.1016/j.canlet.2018.06.016. Epub 2018 Jun 18. Cancer Lett. 2018. PMID: 29928962
599 results