Lu A - Search Results

1

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.

Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Li Y, et al. Among authors: lu a. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10845-10852. doi: 10.1073/pnas.1810524115. Epub 2018 Oct 2. Proc Natl Acad Sci U S A. 2018. PMID: 30279182 Free PMC article.

2

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Lu A, et al. Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008. Cell. 2014. PMID: 24630722 Free PMC article.

3

Structural mechanisms of inflammasome assembly.

Lu A, Wu H. Lu A, et al. FEBS J. 2015 Feb;282(3):435-44. doi: 10.1111/febs.13133. Epub 2014 Nov 21. FEBS J. 2015. PMID: 25354325 Free PMC article. Review.

4

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Zhang L, et al. Among authors: lu a. Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8. Science. 2015. PMID: 26449474 Free PMC article.

5

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Lu A, et al. Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4. Nat Struct Mol Biol. 2016. PMID: 27043298 Free PMC article.

6

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. Schmidt FI, et al. Among authors: lu a. J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11. J Exp Med. 2016. PMID: 27069117 Free PMC article.

7

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.

Fu TM, Li Y, Lu A, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H. Fu TM, et al. Among authors: lu a. Mol Cell. 2016 Oct 20;64(2):236-250. doi: 10.1016/j.molcel.2016.09.009. Epub 2016 Oct 13. Mol Cell. 2016. PMID: 27746017 Free PMC article.

8

Molecular mechanism for NLRP6 inflammasome assembly and activation.

Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Shen C, et al. Among authors: lu a. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057. doi: 10.1073/pnas.1817221116. Epub 2019 Jan 23. Proc Natl Acad Sci U S A. 2019. PMID: 30674671 Free PMC article.

9

Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.

Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Lu A, et al. J Mol Biol. 2014 Apr 3;426(7):1420-7. doi: 10.1016/j.jmb.2013.12.029. Epub 2014 Jan 7. J Mol Biol. 2014. PMID: 24406744 Free PMC article.

10

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.

Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. Vajjhala PR, et al. Among authors: lu a. J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14. J Biol Chem. 2015. PMID: 26468282 Free PMC article.

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