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Structure-guided combination therapy to potently improve the function of mutant CFTRs.
Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL. Veit G, et al. Among authors: edelman a. Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8. Nat Med. 2018. PMID: 30297908 Free PMC article.
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
Colas J, Faure G, Saussereau E, Trudel S, Rabeh WM, Bitam S, Guerrera IC, Fritsch J, Sermet-Gaudelus I, Davezac N, Brouillard F, Lukacs GL, Herrmann H, Ollero M, Edelman A. Colas J, et al. Among authors: edelman a. Hum Mol Genet. 2012 Feb 1;21(3):623-34. doi: 10.1093/hmg/ddr496. Epub 2011 Oct 28. Hum Mol Genet. 2012. PMID: 22038833 Free PMC article.
Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis.
Faure G, Bakouh N, Lourdel S, Odolczyk N, Premchandar A, Servel N, Hatton A, Ostrowski MK, Xu H, Saul FA, Moquereau C, Bitam S, Pranke I, Planelles G, Teulon J, Herrmann H, Roldan A, Zielenkiewicz P, Dadlez M, Lukacs GL, Sermet-Gaudelus I, Ollero M, Corringer PJ, Edelman A. Faure G, et al. Among authors: edelman a. J Mol Biol. 2016 Jul 17;428(14):2898-915. doi: 10.1016/j.jmb.2016.05.016. Epub 2016 May 27. J Mol Biol. 2016. PMID: 27241308
Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.
Simonin J, Bille E, Crambert G, Noel S, Dreano E, Edwards A, Hatton A, Pranke I, Villeret B, Cottart CH, Vrel JP, Urbach V, Baatallah N, Hinzpeter A, Golec A, Touqui L, Nassif X, Galietta LJV, Planelles G, Sallenave JM, Edelman A, Sermet-Gaudelus I. Simonin J, et al. Among authors: edelman a. Sci Rep. 2019 Apr 24;9(1):6516. doi: 10.1038/s41598-019-42751-4. Sci Rep. 2019. PMID: 31019198 Free PMC article.
Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Pranke IM, Chevalier B, Premchandar A, Baatallah N, Tomaszewski KF, Bitam S, Tondelier D, Golec A, Stolk J, Lukacs GL, Hiemstra PS, Dadlez M, Lomas DA, Irving JA, Delaunay-Moisan A, van Anken E, Hinzpeter A, Sermet-Gaudelus I, Edelman A. Pranke IM, et al. Among authors: edelman a. Cell Mol Life Sci. 2022 Sep;79(9):503. doi: 10.1007/s00018-022-04528-3. Epub 2022 Sep 1. Cell Mol Life Sci. 2022. PMID: 36045259
Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.
Odolczyk N, Fritsch J, Norez C, Servel N, da Cunha MF, Bitam S, Kupniewska A, Wiszniewski L, Colas J, Tarnowski K, Tondelier D, Roldan A, Saussereau EL, Melin-Heschel P, Wieczorek G, Lukacs GL, Dadlez M, Faure G, Herrmann H, Ollero M, Becq F, Zielenkiewicz P, Edelman A. Odolczyk N, et al. Among authors: edelman a. EMBO Mol Med. 2013 Oct;5(10):1484-501. doi: 10.1002/emmm.201302699. Epub 2013 Aug 27. EMBO Mol Med. 2013. PMID: 23982976 Free PMC article.
515 results