Zhong X - Search Results

1

Transient CHO expression platform for robust antibody production and its enhanced N-glycan sialylation on therapeutic glycoproteins.

Zhong X, Ma W, Meade CL, Tam AS, Llewellyn E, Cornell R, Cote K, Scarcelli JJ, Marshall JK, Tzvetkova B, Figueroa B, DiNino D, Sievers A, Lee C, Guo J, Mahan E, Francis C, Lam K, D'Antona AM, Zollner R, Zhu HL, Kriz R, Somers W, Lin L. Zhong X, et al. Biotechnol Prog. 2019 Jan;35(1):e2724. doi: 10.1002/btpr.2724. Epub 2018 Oct 27. Biotechnol Prog. 2019. PMID: 30299005

2

N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression.

Zhong X, Kriz R, Seehra J, Kumar R. Zhong X, et al. FEBS Lett. 2004 Mar 26;562(1-3):111-7. doi: 10.1016/S0014-5793(04)00191-7. FEBS Lett. 2004. PMID: 15044010 Free article.

3

Distinctive roles of endoplasmic reticulum and golgi glycosylation in functional surface expression of mammalian E-NTPDase1, CD39.

Zhong X, Kriz R, Kumar R, Guidotti G. Zhong X, et al. Biochim Biophys Acta. 2005 May 25;1723(1-3):143-50. doi: 10.1016/j.bbagen.2005.01.010. Epub 2005 Feb 3. Biochim Biophys Acta. 2005. PMID: 15777625

4

Regulation of secreted Frizzled-related protein-1 by heparin.

Zhong X, Desilva T, Lin L, Bodine P, Bhat RA, Presman E, Pocas J, Stahl M, Kriz R. Zhong X, et al. J Biol Chem. 2007 Jul 13;282(28):20523-33. doi: 10.1074/jbc.M609096200. Epub 2007 May 11. J Biol Chem. 2007. PMID: 17500071 Free article.

5

Expression, purification and crystallization of the ecto-enzymatic domain of rat E-NTPDase1 CD39.

Zhong X, Buddha M, Guidotti G, Kriz R, Somers W, Mosyak L. Zhong X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1063-5. doi: 10.1107/S1744309108032569. Epub 2008 Oct 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18997343 Free PMC article.

6

Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1.

Zhong X, Pocas J, Liu Y, Wu PW, Mosyak L, Somers W, Kriz R. Zhong X, et al. FEBS Lett. 2009 Mar 18;583(6):1034-8. doi: 10.1016/j.febslet.2009.02.034. Epub 2009 Mar 1. FEBS Lett. 2009. PMID: 19254717 Free article.

7

Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.

Zhong X, Cooley C, Seth N, Juo ZS, Presman E, Resendes N, Kumar R, Allen M, Mosyak L, Stahl M, Somers W, Kriz R. Zhong X, et al. Biotechnol Bioeng. 2012 Jul;109(7):1723-34. doi: 10.1002/bit.24448. Epub 2012 Feb 2. Biotechnol Bioeng. 2012. PMID: 22252477

8

Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.

Zhong X, Kieras E, Sousa E, D'Antona A, Baber JC, He T, Desharnais J, Wood L, Luxenberg D, Stahl M, Kriz R, Lin L, Somers W, Fitz LJ, Wright JF. Zhong X, et al. J Biol Chem. 2013 Jan 11;288(2):1409-19. doi: 10.1074/jbc.M112.417717. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184956 Free PMC article.

9

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O. Fennell BJ, et al. Among authors: zhong x. MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21. MAbs. 2013. PMID: 23995618 Free PMC article.

10

Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells.

Zhong X, He T, Prashad AS, Wang W, Cohen J, Ferguson D, Tam AS, Sousa E, Lin L, Tchistiakova L, Gatto S, D'Antona A, Luan YT, Ma W, Zollner R, Zhou J, Arve B, Somers W, Kriz R. Zhong X, et al. J Biotechnol. 2017 Apr 20;248:48-58. doi: 10.1016/j.jbiotec.2017.03.006. Epub 2017 Mar 11. J Biotechnol. 2017. PMID: 28300660

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