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Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B. Gorelik A, et al. Among authors: piomelli d. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10032-E10040. doi: 10.1073/pnas.1811759115. Epub 2018 Oct 9. Proc Natl Acad Sci U S A. 2018. PMID: 30301806 Free PMC article.
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.
Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. Solorzano C, et al. Among authors: piomelli d. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20966-71. doi: 10.1073/pnas.0907417106. Epub 2009 Nov 19. Proc Natl Acad Sci U S A. 2009. PMID: 19926854 Free PMC article.
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.
Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. Ribeiro A, et al. Among authors: piomelli d. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. doi: 10.1021/acschembio.5b00114. Epub 2015 Apr 15. ACS Chem Biol. 2015. PMID: 25874594 Free PMC article.
Activity-Based Probe for N-Acylethanolamine Acid Amidase.
Romeo E, Ponzano S, Armirotti A, Summa M, Bertozzi F, Garau G, Bandiera T, Piomelli D. Romeo E, et al. Among authors: piomelli d. ACS Chem Biol. 2015 Sep 18;10(9):2057-2064. doi: 10.1021/acschembio.5b00197. Epub 2015 Jun 23. ACS Chem Biol. 2015. PMID: 26102511 Free PMC article.
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.
Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D. Nuzzi A, et al. Among authors: piomelli d. Eur J Med Chem. 2016 Mar 23;111:138-59. doi: 10.1016/j.ejmech.2016.01.046. Epub 2016 Jan 27. Eur J Med Chem. 2016. PMID: 26866968 Free article.
Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis.
Migliore M Dr, Pontis S Dr, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D. Migliore M Dr, et al. Among authors: piomelli d. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. doi: 10.1002/anie.201603746. Epub 2016 Jul 12. Angew Chem Int Ed Engl. 2016. PMID: 27404798 Free PMC article.
451 results