C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity.
Mosthaf L, Berti L, Kellerer M, Mushack J, Seffer E, Bossenmaier B, Coghlan M, Siddle K, Ullrich A, Häring HU.
Mosthaf L, et al. Among authors: berti l.
Eur J Biochem. 1995 Feb 1;227(3):787-91. doi: 10.1111/j.1432-1033.1995.tb20202.x.
Eur J Biochem. 1995.
PMID: 7867639
Free article.
We have previously shown, in rat-1 fibroblasts which stably overexpress high levels of human insulin receptor (HIR), that high glucose levels induce an inhibition of insulin receptor tyrosine kinase (IRK) activity [Berti, L., Mosthaf, L., Kellerer, M., Tippme …
We have previously shown, in rat-1 fibroblasts which stably overexpress high levels of human insulin receptor (HIR), that high glucose level …