Leff RD - Search Results

1

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis.

Gerber DE, Beg MS, Fattah F, Frankel AE, Fatunde O, Arriaga Y, Dowell JE, Bisen A, Leff RD, Meek CC, Putnam WC, Kallem RR, Subramaniyan I, Dong Y, Bolluyt J, Sarode V, Luo X, Xie Y, Schwartz B, Boothman DA. Gerber DE, et al. Among authors: leff rd. Br J Cancer. 2018 Oct;119(8):928-936. doi: 10.1038/s41416-018-0278-4. Epub 2018 Oct 15. Br J Cancer. 2018. PMID: 30318513 Free PMC article. Clinical Trial.

2

Phase 1 study of romidepsin plus erlotinib in advanced non-small cell lung cancer.

Gerber DE, Boothman DA, Fattah FJ, Dong Y, Zhu H, Skelton RA, Priddy LL, Vo P, Dowell JE, Sarode V, Leff R, Meek C, Xie Y, Schiller JH. Gerber DE, et al. Lung Cancer. 2015 Dec;90(3):534-41. doi: 10.1016/j.lungcan.2015.10.008. Epub 2015 Oct 9. Lung Cancer. 2015. PMID: 26474959 Free PMC article. Clinical Trial.

3

Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.

Beg MS, Huang X, Silvers MA, Gerber DE, Bolluyt J, Sarode V, Fattah F, Deberardinis RJ, Merritt ME, Xie XJ, Leff R, Laheru D, Boothman DA. Beg MS, et al. J Surg Oncol. 2017 Jul;116(1):83-88. doi: 10.1002/jso.24624. Epub 2017 Mar 27. J Surg Oncol. 2017. PMID: 28346693 Free PMC article.

4

Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.

Gerber DE, Putnam WC, Fattah FJ, Kernstine KH, Brekken RA, Pedrosa I, Skelton R, Saltarski JM, Lenkinski RE, Leff RD, Ahn C, Padmanabhan C, Chembukar V, Kasiri S, Kallem RR, Subramaniyan I, Yuan Q, Do QN, Xi Y, Reznik SI, Pelosof L, Faubert B, DeBerardinis RJ, Kim J. Gerber DE, et al. Among authors: leff rd. Clin Cancer Res. 2020 Nov 15;26(22):6017-6027. doi: 10.1158/1078-0432.CCR-20-1916. Epub 2020 Aug 26. Clin Cancer Res. 2020. PMID: 32847935 Free PMC article. Clinical Trial.

5

Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability.

Srivastava S, Pasipanodya JG, Meek C, Leff R, Gumbo T. Srivastava S, et al. J Infect Dis. 2011 Dec 15;204(12):1951-9. doi: 10.1093/infdis/jir658. Epub 2011 Oct 21. J Infect Dis. 2011. PMID: 22021624 Free PMC article.

6

Pharmacokinetics-pharmacodynamics of pyrazinamide in a novel in vitro model of tuberculosis for sterilizing effect: a paradigm for faster assessment of new antituberculosis drugs.

Gumbo T, Dona CS, Meek C, Leff R. Gumbo T, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3197-204. doi: 10.1128/AAC.01681-08. Epub 2009 May 18. Antimicrob Agents Chemother. 2009. PMID: 19451303 Free PMC article.

7

Efflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol.

Srivastava S, Musuka S, Sherman C, Meek C, Leff R, Gumbo T. Srivastava S, et al. J Infect Dis. 2010 Apr 15;201(8):1225-31. doi: 10.1086/651377. J Infect Dis. 2010. PMID: 20210628 Free PMC article.

8

Ethambutol optimal clinical dose and susceptibility breakpoint identification by use of a novel pharmacokinetic-pharmacodynamic model of disseminated intracellular Mycobacterium avium.

Deshpande D, Srivastava S, Meek C, Leff R, Gumbo T. Deshpande D, et al. Antimicrob Agents Chemother. 2010 May;54(5):1728-33. doi: 10.1128/AAC.01355-09. Epub 2010 Mar 15. Antimicrob Agents Chemother. 2010. PMID: 20231389 Free PMC article.

9

Moxifloxacin pharmacokinetics/pharmacodynamics and optimal dose and susceptibility breakpoint identification for treatment of disseminated Mycobacterium avium infection.

Deshpande D, Srivastava S, Meek C, Leff R, Hall GS, Gumbo T. Deshpande D, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2534-9. doi: 10.1128/AAC.01761-09. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385862 Free PMC article.

10

Pharmacokinetic mismatch does not lead to emergence of isoniazid- or rifampin-resistant Mycobacterium tuberculosis but to better antimicrobial effect: a new paradigm for antituberculosis drug scheduling.

Srivastava S, Sherman C, Meek C, Leff R, Gumbo T. Srivastava S, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5085-9. doi: 10.1128/AAC.00269-11. Epub 2011 Sep 6. Antimicrob Agents Chemother. 2011. PMID: 21896907 Free PMC article.

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