An LK - Search Results

1

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.

Zhang XR, Wang HW, Tang WL, Zhang Y, Yang H, Hu DX, Ravji A, Marchand C, Kiselev E, Ofori-Atta K, Agama K, Pommier Y, An LK. Zhang XR, et al. Among authors: an lk. J Med Chem. 2018 Nov 21;61(22):9908-9930. doi: 10.1021/acs.jmedchem.8b00639. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30336023 Free PMC article.

2

Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.

Tang H, Wang XD, Wei YB, Huang SL, Huang ZS, Tan JH, An LK, Wu JY, Chan AS, Gu LQ. Tang H, et al. Among authors: an lk. Eur J Med Chem. 2008 May;43(5):973-80. doi: 10.1016/j.ejmech.2007.07.004. Epub 2007 Jul 15. Eur J Med Chem. 2008. PMID: 17720282

3

Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives.

Cheng Y, An LK, Wu N, Wang XD, Bu XZ, Huang ZS, Gu LQ. Cheng Y, et al. Among authors: an lk. Bioorg Med Chem. 2008 Apr 15;16(8):4617-25. doi: 10.1016/j.bmc.2008.02.036. Epub 2008 Feb 15. Bioorg Med Chem. 2008. PMID: 18296054

4

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.

Qiu X, Liu Z, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ, Huang ZS, Gu LQ. Qiu X, et al. Among authors: an lk. Bioorg Med Chem. 2008 Sep 1;16(17):8035-41. doi: 10.1016/j.bmc.2008.07.054. Epub 2008 Jul 24. Bioorg Med Chem. 2008. PMID: 18678491

5

Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.

Wang B, Mai YC, Li Y, Hou JQ, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS. Wang B, et al. Among authors: an lk. Eur J Med Chem. 2010 Apr;45(4):1415-23. doi: 10.1016/j.ejmech.2009.12.044. Epub 2010 Jan 4. Eur J Med Chem. 2010. PMID: 20079560

6

Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.

Wang XD, Ou TM, Lu YJ, Li Z, Xu Z, Xi C, Tan JH, Huang SL, An LK, Li D, Gu LQ, Huang ZS. Wang XD, et al. Among authors: an lk. J Med Chem. 2010 Jun 10;53(11):4390-8. doi: 10.1021/jm100445e. J Med Chem. 2010. PMID: 20481493

7

Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.

An ZY, Yan YY, Peng D, Ou TM, Tan JH, Huang SL, An LK, Gu LQ, Huang ZS. An ZY, et al. Among authors: an lk. Eur J Med Chem. 2010 Sep;45(9):3895-903. doi: 10.1016/j.ejmech.2010.05.043. Epub 2010 May 26. Eur J Med Chem. 2010. PMID: 20554355

8

Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors.

Shen DQ, Wu ZP, Wu XW, An ZY, Bu XZ, Gu LQ, Huang ZS, An LK. Shen DQ, et al. Among authors: an zy, an lk. Eur J Med Chem. 2010 Sep;45(9):3938-42. doi: 10.1016/j.ejmech.2010.05.048. Epub 2010 Jun 1. Eur J Med Chem. 2010. PMID: 20638158

9

A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.

Wu N, Wu XW, Agama K, Pommier Y, Du J, Li D, Gu LQ, Huang ZS, An LK. Wu N, et al. Among authors: an lk. Biochemistry. 2010 Nov 30;49(47):10131-6. doi: 10.1021/bi1009419. Epub 2010 Nov 8. Biochemistry. 2010. PMID: 21033700 Free PMC article.

10

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.

Chen SB, Tan JH, Ou TM, Huang SL, An LK, Luo HB, Li D, Gu LQ, Huang ZS. Chen SB, et al. Among authors: an lk. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1004-9. doi: 10.1016/j.bmcl.2010.12.019. Epub 2010 Dec 10. Bioorg Med Chem Lett. 2011. PMID: 21211968

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